{
  "url": "https://dantelabs.com/traits/left-bundle-branch-block",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "left-bundle-branch-block",
    "id": "HP:0011713",
    "name": "Left bundle branch block",
    "definition": "A conduction block of the left branch of the bundle of His. This manifests as a generalized disturbance of QRS morphology on EKG.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "bundle-branch-block",
        "name": "Bundle branch block",
        "url": "https://dantelabs.com/traits/bundle-branch-block"
      }
    ],
    "narrower": [
      {
        "slug": "left-anterior-fascicular-block",
        "name": "Left anterior fascicular block",
        "genes": 8,
        "url": "https://dantelabs.com/traits/left-anterior-fascicular-block"
      },
      {
        "slug": "left-posterior-fascicular-block",
        "name": "Left posterior fascicular block",
        "genes": 1,
        "url": "https://dantelabs.com/traits/left-posterior-fascicular-block"
      }
    ],
    "genes": [
      {
        "slug": "dsg2",
        "symbol": "DSG2",
        "hgnc": "HGNC:3049",
        "name": "desmoglein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsg2"
      },
      {
        "slug": "emd",
        "symbol": "EMD",
        "hgnc": "HGNC:3331",
        "name": "emerin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emd"
      },
      {
        "slug": "nrap",
        "symbol": "NRAP",
        "hgnc": "HGNC:7988",
        "name": "nebulin related anchoring protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nrap"
      },
      {
        "slug": "polg2",
        "symbol": "POLG2",
        "hgnc": "HGNC:9180",
        "name": "DNA polymerase gamma 2, accessory subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg2"
      },
      {
        "slug": "cdh2",
        "symbol": "CDH2",
        "hgnc": "HGNC:1759",
        "name": "cadherin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh2"
      },
      {
        "slug": "ctnna3",
        "symbol": "CTNNA3",
        "hgnc": "HGNC:2511",
        "name": "catenin alpha 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnna3"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen1"
      },
      {
        "slug": "actc1",
        "symbol": "ACTC1",
        "hgnc": "HGNC:143",
        "name": "actin alpha cardiac muscle 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actc1"
      },
      {
        "slug": "flnc",
        "symbol": "FLNC",
        "hgnc": "HGNC:3756",
        "name": "filamin C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flnc"
      },
      {
        "slug": "ldb3",
        "symbol": "LDB3",
        "hgnc": "HGNC:15710",
        "name": "LIM domain binding 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldb3"
      },
      {
        "slug": "myl2",
        "symbol": "MYL2",
        "hgnc": "HGNC:7583",
        "name": "myosin light chain 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myl2"
      },
      {
        "slug": "myoz2",
        "symbol": "MYOZ2",
        "hgnc": "HGNC:1330",
        "name": "myozenin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myoz2"
      },
      {
        "slug": "prkag2",
        "symbol": "PRKAG2",
        "hgnc": "HGNC:9386",
        "name": "protein kinase AMP-activated non-catalytic subunit gamma 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkag2"
      },
      {
        "slug": "psen2",
        "symbol": "PSEN2",
        "hgnc": "HGNC:9509",
        "name": "presenilin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen2"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "hgnc": "HGNC:10593",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn5a"
      },
      {
        "slug": "mybpc3",
        "symbol": "MYBPC3",
        "hgnc": "HGNC:7551",
        "name": "myosin binding protein C3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mybpc3"
      }
    ]
  }
}