{
  "url": "https://dantelabs.com/traits/isomerism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "isomerism",
    "id": "HP:0031853",
    "name": "Isomerism",
    "definition": "Isomerism in the context of the congenitally malformed heart is defined as a situation where some paired structures on opposite sides of the left-right axis of the body are, in morphologic terms, symmetrical mirror images of each other.",
    "synonyms": [],
    "systems": [
      {
        "slug": "growth-abnormality",
        "name": "Growth abnormality",
        "url": "https://dantelabs.com/traits/growth-abnormality"
      }
    ],
    "broader": [
      {
        "slug": "heterotaxy",
        "name": "Heterotaxy",
        "url": "https://dantelabs.com/traits/heterotaxy"
      }
    ],
    "narrower": [
      {
        "slug": "left-isomerism",
        "name": "Left Isomerism",
        "genes": 4,
        "url": "https://dantelabs.com/traits/left-isomerism"
      },
      {
        "slug": "bronchial-isomerism",
        "name": "Bronchial isomerism",
        "genes": 1,
        "url": "https://dantelabs.com/traits/bronchial-isomerism"
      },
      {
        "slug": "right-isomerism",
        "name": "Right isomerism",
        "genes": 0,
        "url": "https://dantelabs.com/traits/right-isomerism"
      }
    ],
    "genes": [
      {
        "slug": "dand5",
        "symbol": "DAND5",
        "hgnc": "HGNC:26780",
        "name": "DAN domain BMP antagonist family member 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dand5"
      },
      {
        "slug": "smad2",
        "symbol": "SMAD2",
        "hgnc": "HGNC:6768",
        "name": "SMAD family member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad2"
      },
      {
        "slug": "zic3",
        "symbol": "ZIC3",
        "hgnc": "HGNC:12874",
        "name": "Zic family zinc finger 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zic3"
      }
    ]
  }
}