{
  "url": "https://dantelabs.com/traits/increased-skull-ossification",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-skull-ossification",
    "id": "HP:0004330",
    "name": "Increased calcification of skull",
    "label": "Increased skull ossification",
    "definition": "An increase in the magnitude or amount of ossification of the skull.",
    "synonyms": [
      "Increased Mineralization of skull",
      "Hyperossification of skull",
      "Hyperostosis of skull",
      "Sclerosis of bones of skull",
      "Sclerosis of skull"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-skull-ossification",
        "name": "Abnormality of bone formation of cranium",
        "url": "https://dantelabs.com/traits/abnormality-of-skull-ossification"
      },
      {
        "slug": "increased-bone-mineral-density",
        "name": "Increased bone mineral density",
        "url": "https://dantelabs.com/traits/increased-bone-mineral-density"
      }
    ],
    "narrower": [
      {
        "slug": "dense-calvaria",
        "name": "Dense skull cap",
        "genes": 3,
        "url": "https://dantelabs.com/traits/dense-calvaria"
      },
      {
        "slug": "increased-spinal-bone-density",
        "name": "Concrete spinal bone",
        "genes": 1,
        "url": "https://dantelabs.com/traits/increased-spinal-bone-density"
      }
    ],
    "genes": [
      {
        "slug": "csf1r",
        "symbol": "CSF1R",
        "hgnc": "HGNC:2433",
        "name": "colony stimulating factor 1 receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf1r"
      },
      {
        "slug": "rbl2",
        "symbol": "RBL2",
        "hgnc": "HGNC:9894",
        "name": "RB transcriptional corepressor like 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbl2"
      },
      {
        "slug": "hhat",
        "symbol": "HHAT",
        "hgnc": "HGNC:18270",
        "name": "hedgehog acyltransferase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hhat"
      },
      {
        "slug": "borcs5",
        "symbol": "BORCS5",
        "hgnc": "HGNC:17950",
        "name": "BLOC-1 related complex subunit 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/borcs5"
      }
    ]
  }
}