{
  "url": "https://dantelabs.com/traits/hematochezia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hematochezia",
    "id": "HP:0002573",
    "name": "Rectal bleeding",
    "label": "Hematochezia",
    "definition": "The passage of fresh (red) blood per anus, usually in or with stools. Most rectal bleeding comes from the colon, rectum, or anus.",
    "synonyms": [
      "Recurrent rectal bleeding"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "bloody-diarrhea",
        "name": "Bloody diarrhea",
        "url": "https://dantelabs.com/traits/bloody-diarrhea"
      },
      {
        "slug": "gastrointestinal-hemorrhage",
        "name": "Gastrointestinal bleeding",
        "url": "https://dantelabs.com/traits/gastrointestinal-hemorrhage"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "amacr",
        "symbol": "AMACR",
        "hgnc": "HGNC:451",
        "name": "alpha-methylacyl-CoA racemase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/amacr"
      },
      {
        "slug": "arpc5",
        "symbol": "ARPC5",
        "hgnc": "HGNC:708",
        "name": "actin related protein 2/3 complex subunit 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arpc5"
      },
      {
        "slug": "cyp7b1",
        "symbol": "CYP7B1",
        "hgnc": "HGNC:2652",
        "name": "cytochrome P450 family 7 subfamily B member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp7b1"
      },
      {
        "slug": "il10ra",
        "symbol": "IL10RA",
        "hgnc": "HGNC:5964",
        "name": "interleukin 10 receptor subunit alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10ra"
      },
      {
        "slug": "oas2",
        "symbol": "OAS2",
        "hgnc": "HGNC:8087",
        "name": "2'-5'-oligoadenylate synthetase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/oas2"
      },
      {
        "slug": "plvap",
        "symbol": "PLVAP",
        "hgnc": "HGNC:13635",
        "name": "plasmalemma vesicle associated protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plvap"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/was"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "grem1",
        "symbol": "GREM1",
        "hgnc": "HGNC:2001",
        "name": "gremlin 1, DAN family BMP antagonist",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grem1"
      },
      {
        "slug": "arpc1b",
        "symbol": "ARPC1B",
        "hgnc": "HGNC:704",
        "name": "actin related protein 2/3 complex subunit 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arpc1b"
      },
      {
        "slug": "eng",
        "symbol": "ENG",
        "hgnc": "HGNC:3349",
        "name": "endoglin",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/eng"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "rbck1",
        "symbol": "RBCK1",
        "hgnc": "HGNC:15864",
        "name": "RANBP2-type and C3HC4-type zinc finger containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbck1"
      },
      {
        "slug": "sharpin",
        "symbol": "SHARPIN",
        "hgnc": "HGNC:25321",
        "name": "SHANK associated RH domain interactor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sharpin"
      },
      {
        "slug": "smad4",
        "symbol": "SMAD4",
        "hgnc": "HGNC:6770",
        "name": "SMAD family member 4",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smad4"
      },
      {
        "slug": "ttc7a",
        "symbol": "TTC7A",
        "hgnc": "HGNC:19750",
        "name": "tetratricopeptide repeat domain 7A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc7a"
      },
      {
        "slug": "ifih1",
        "symbol": "IFIH1",
        "hgnc": "HGNC:18873",
        "name": "interferon induced with helicase C domain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifih1"
      },
      {
        "slug": "taok1",
        "symbol": "TAOK1",
        "hgnc": "HGNC:29259",
        "name": "TAO kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taok1"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "hgnc": "HGNC:3542",
        "name": "coagulation factor V",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f5"
      },
      {
        "slug": "acvrl1",
        "symbol": "ACVRL1",
        "hgnc": "HGNC:175",
        "name": "activin A receptor like type 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acvrl1"
      },
      {
        "slug": "hps1",
        "symbol": "HPS1",
        "hgnc": "HGNC:5163",
        "name": "HPS1 biogenesis of lysosomal organelles complex 3 subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps1"
      }
    ]
  }
}