{
  "url": "https://dantelabs.com/traits/facial-hyperostosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "facial-hyperostosis",
    "id": "HP:0005465",
    "name": "Enlargement of facial bones",
    "label": "Facial hyperostosis",
    "definition": "Excessive growth (overgrowth) of the facial bones, that is of the facial skeleton.",
    "synonyms": [
      "Enlargement of facial skeleton",
      "Enlargement of the facial bones",
      "Excessive growth of facial bones",
      "Excessive growth of facial skeleton",
      "Increase in size of the facial bones",
      "Overgrowth of facial bones",
      "Overgrowth of facial skeleton",
      "Overgrowth of the facial bones",
      "Hyperostosis of facial bones",
      "Hyperostosis of facial skeleton",
      "Hypertrophy of the facial bones"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "craniofacial-hyperostosis",
        "name": "Enlargement of craniofacial bones",
        "url": "https://dantelabs.com/traits/craniofacial-hyperostosis"
      }
    ],
    "narrower": [
      {
        "slug": "facial-palsy-secondary-to-cranial-hyperostosis",
        "name": "Facial palsy secondary to cranial hyperostosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/facial-palsy-secondary-to-cranial-hyperostosis"
      },
      {
        "slug": "mandibular-hyperostosis",
        "name": "Thick lower jaw bone",
        "genes": 1,
        "url": "https://dantelabs.com/traits/mandibular-hyperostosis"
      }
    ],
    "genes": [
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "amer1",
        "symbol": "AMER1",
        "hgnc": "HGNC:26837",
        "name": "APC membrane recruitment protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amer1"
      },
      {
        "slug": "ctnnb1",
        "symbol": "CTNNB1",
        "hgnc": "HGNC:2514",
        "name": "catenin beta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnb1"
      },
      {
        "slug": "ptdss1",
        "symbol": "PTDSS1",
        "hgnc": "HGNC:9587",
        "name": "phosphatidylserine synthase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptdss1"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      }
    ]
  }
}