{
  "url": "https://dantelabs.com/traits/drusen",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "drusen",
    "id": "HP:0011510",
    "name": "Drusen",
    "definition": "Drusen (singular, 'druse') are tiny yellow or white accumulations of extracellular material (lipofuscin) that build up in the Bruch membrane of the eye.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "yellow-white-retinal-lesion",
        "name": "Yellow/white retinal lesion",
        "url": "https://dantelabs.com/traits/yellow-white-retinal-lesion"
      }
    ],
    "narrower": [
      {
        "slug": "optic-disc-drusen",
        "name": "Optic disc drusen",
        "genes": 119,
        "url": "https://dantelabs.com/traits/optic-disc-drusen"
      },
      {
        "slug": "macular-drusen",
        "name": "Macular drusen",
        "genes": 8,
        "url": "https://dantelabs.com/traits/macular-drusen"
      }
    ],
    "genes": [
      {
        "slug": "espn",
        "symbol": "ESPN",
        "hgnc": "HGNC:13281",
        "name": "espin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/espn"
      },
      {
        "slug": "c1qtnf5",
        "symbol": "C1QTNF5",
        "hgnc": "HGNC:14344",
        "name": "C1q and TNF related 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1qtnf5"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "guca1a",
        "symbol": "GUCA1A",
        "hgnc": "HGNC:4678",
        "name": "guanylate cyclase activator 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/guca1a"
      },
      {
        "slug": "gucy2d",
        "symbol": "GUCY2D",
        "hgnc": "HGNC:4689",
        "name": "guanylate cyclase 2D, retinal",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gucy2d"
      },
      {
        "slug": "prph2",
        "symbol": "PRPH2",
        "hgnc": "HGNC:9942",
        "name": "peripherin 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prph2"
      },
      {
        "slug": "cfh",
        "symbol": "CFH",
        "hgnc": "HGNC:4883",
        "name": "complement factor H",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfh"
      },
      {
        "slug": "cfi",
        "symbol": "CFI",
        "hgnc": "HGNC:5394",
        "name": "complement factor I",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfi"
      },
      {
        "slug": "ctnna1",
        "symbol": "CTNNA1",
        "hgnc": "HGNC:2509",
        "name": "catenin alpha 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnna1"
      },
      {
        "slug": "fbln5",
        "symbol": "FBLN5",
        "hgnc": "HGNC:3602",
        "name": "fibulin 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbln5"
      },
      {
        "slug": "impg1",
        "symbol": "IMPG1",
        "hgnc": "HGNC:6055",
        "name": "interphotoreceptor matrix proteoglycan 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/impg1"
      }
    ]
  }
}