{
  "url": "https://dantelabs.com/traits/delusion",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "delusion",
    "id": "HP:0000746",
    "name": "Delusions",
    "label": "Delusion",
    "definition": "A delusion is a fixed false belief held despite evidence to the contrary. The term delusion broadly encompasses all false judgments that possess the following external characteristics to a significant, albeit unspecified, extent: (1) they are held with an exceptional level of conviction, accompanied by an unparalleled subjective certainty; (2) there is an inability to consider alternative experiences or compelling counter-arguments; (3) the content of the belief is impossible.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-judgment",
        "name": "Abnormal judgment",
        "url": "https://dantelabs.com/traits/abnormal-judgment"
      },
      {
        "slug": "disorder-of-thought-content",
        "name": "Disorder of thought content",
        "url": "https://dantelabs.com/traits/disorder-of-thought-content"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "htra1",
        "symbol": "HTRA1",
        "hgnc": "HGNC:9476",
        "name": "HtrA serine peptidase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htra1"
      },
      {
        "slug": "arsa",
        "symbol": "ARSA",
        "hgnc": "HGNC:713",
        "name": "arylsulfatase A",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/arsa"
      },
      {
        "slug": "csf1r",
        "symbol": "CSF1R",
        "hgnc": "HGNC:2433",
        "name": "colony stimulating factor 1 receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf1r"
      },
      {
        "slug": "htt",
        "symbol": "HTT",
        "hgnc": "HGNC:4851",
        "name": "huntingtin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htt"
      },
      {
        "slug": "prnp",
        "symbol": "PRNP",
        "hgnc": "HGNC:9449",
        "name": "prion protein (Kanno blood group)",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/prnp"
      },
      {
        "slug": "psap",
        "symbol": "PSAP",
        "hgnc": "HGNC:9498",
        "name": "prosaposin",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/psap"
      },
      {
        "slug": "slc25a13",
        "symbol": "SLC25A13",
        "hgnc": "HGNC:10983",
        "name": "solute carrier family 25 member 13",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a13"
      },
      {
        "slug": "slc2a3",
        "symbol": "SLC2A3",
        "hgnc": "HGNC:11007",
        "name": "solute carrier family 2 member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a3"
      },
      {
        "slug": "man2b1",
        "symbol": "MAN2B1",
        "hgnc": "HGNC:6826",
        "name": "mannosidase alpha class 2B member 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/man2b1"
      },
      {
        "slug": "pla2g6",
        "symbol": "PLA2G6",
        "hgnc": "HGNC:9039",
        "name": "phospholipase A2 group VI",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pla2g6"
      },
      {
        "slug": "trank1",
        "symbol": "TRANK1",
        "hgnc": "HGNC:29011",
        "name": "tetratricopeptide repeat and ankyrin repeat containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trank1"
      },
      {
        "slug": "apol2",
        "symbol": "APOL2",
        "hgnc": "HGNC:619",
        "name": "apolipoprotein L2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apol2"
      },
      {
        "slug": "c9orf72",
        "symbol": "C9orf72",
        "hgnc": "HGNC:28337",
        "name": "C9orf72-SMCR8 complex subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c9orf72"
      },
      {
        "slug": "chi3l1",
        "symbol": "CHI3L1",
        "hgnc": "HGNC:1932",
        "name": "chitinase 3 like 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chi3l1"
      },
      {
        "slug": "cyp27a1",
        "symbol": "CYP27A1",
        "hgnc": "HGNC:2605",
        "name": "cytochrome P450 family 27 subfamily A member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp27a1"
      },
      {
        "slug": "daoa",
        "symbol": "DAOA",
        "hgnc": "HGNC:21191",
        "name": "D-amino acid oxidase activator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/daoa"
      },
      {
        "slug": "disc2",
        "symbol": "DISC2",
        "hgnc": "HGNC:2889",
        "name": "disrupted in schizophrenia 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/disc2"
      },
      {
        "slug": "drd3",
        "symbol": "DRD3",
        "hgnc": "HGNC:3024",
        "name": "dopamine receptor D3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drd3"
      },
      {
        "slug": "eif2b1",
        "symbol": "EIF2B1",
        "hgnc": "HGNC:3257",
        "name": "eukaryotic translation initiation factor 2B subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2b1"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "hla-dqb1",
        "symbol": "HLA-DQB1",
        "hgnc": "HGNC:4944",
        "name": "major histocompatibility complex, class II, DQ beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dqb1"
      },
      {
        "slug": "htr2a",
        "symbol": "HTR2A",
        "hgnc": "HGNC:5293",
        "name": "5-hydroxytryptamine receptor 2A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htr2a"
      },
      {
        "slug": "jph3",
        "symbol": "JPH3",
        "hgnc": "HGNC:14203",
        "name": "junctophilin 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jph3"
      },
      {
        "slug": "mthfr",
        "symbol": "MTHFR",
        "hgnc": "HGNC:7436",
        "name": "methylenetetrahydrofolate reductase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mthfr"
      },
      {
        "slug": "ppp2r2b",
        "symbol": "PPP2R2B",
        "hgnc": "HGNC:9305",
        "name": "protein phosphatase 2 regulatory subunit Bbeta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp2r2b"
      },
      {
        "slug": "rtn4r",
        "symbol": "RTN4R",
        "hgnc": "HGNC:18601",
        "name": "reticulon 4 receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rtn4r"
      },
      {
        "slug": "snca",
        "symbol": "SNCA",
        "hgnc": "HGNC:11138",
        "name": "synuclein alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snca"
      },
      {
        "slug": "sncb",
        "symbol": "SNCB",
        "hgnc": "HGNC:11140",
        "name": "synuclein beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sncb"
      },
      {
        "slug": "syn2",
        "symbol": "SYN2",
        "hgnc": "HGNC:11495",
        "name": "synapsin II",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syn2"
      }
    ]
  }
}