{
  "url": "https://dantelabs.com/traits/decreased-circulating-complement-c4-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "decreased-circulating-complement-c4-concentration",
    "id": "HP:0045042",
    "name": "Decreased circulating complement C4 concentration",
    "definition": "Concentration of the complement component C4 in the blood circulation below the lower limit of normal.",
    "synonyms": [
      "Decreased serum complement C4",
      "Decreased serum complement C4 level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "reduced-circulating-complement-concentration",
        "name": "Reduced circulating complement concentration",
        "url": "https://dantelabs.com/traits/reduced-circulating-complement-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dnase1l3",
        "symbol": "DNASE1L3",
        "hgnc": "HGNC:2959",
        "name": "deoxyribonuclease 1L3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnase1l3"
      },
      {
        "slug": "plcg1",
        "symbol": "PLCG1",
        "hgnc": "HGNC:9065",
        "name": "phospholipase C gamma 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plcg1"
      },
      {
        "slug": "serping1",
        "symbol": "SERPING1",
        "hgnc": "HGNC:1228",
        "name": "serpin family G member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serping1"
      },
      {
        "slug": "irak1",
        "symbol": "IRAK1",
        "hgnc": "HGNC:6112",
        "name": "interleukin 1 receptor associated kinase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/irak1"
      },
      {
        "slug": "sat1",
        "symbol": "SAT1",
        "hgnc": "HGNC:10540",
        "name": "spermidine/spermine N1-acetyltransferase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sat1"
      },
      {
        "slug": "spp1",
        "symbol": "SPP1",
        "hgnc": "HGNC:11255",
        "name": "secreted phosphoprotein 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spp1"
      },
      {
        "slug": "stat4",
        "symbol": "STAT4",
        "hgnc": "HGNC:11365",
        "name": "signal transducer and activator of transcription 4",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/stat4"
      },
      {
        "slug": "bank1",
        "symbol": "BANK1",
        "hgnc": "HGNC:18233",
        "name": "B cell scaffold protein with ankyrin repeats 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bank1"
      },
      {
        "slug": "blk",
        "symbol": "BLK",
        "hgnc": "HGNC:1057",
        "name": "BLK proto-oncogene, Src family tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blk"
      },
      {
        "slug": "c4a",
        "symbol": "C4A",
        "hgnc": "HGNC:1323",
        "name": "complement C4A (Chido/Rodgers blood group)",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/c4a"
      },
      {
        "slug": "c4b",
        "symbol": "C4B",
        "hgnc": "HGNC:1324",
        "name": "complement C4B (Chido/Rodgers blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c4b"
      },
      {
        "slug": "cr2",
        "symbol": "CR2",
        "hgnc": "HGNC:2336",
        "name": "complement C3d receptor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cr2"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "dnase1",
        "symbol": "DNASE1",
        "hgnc": "HGNC:2956",
        "name": "deoxyribonuclease 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnase1"
      },
      {
        "slug": "ets1",
        "symbol": "ETS1",
        "hgnc": "HGNC:3488",
        "name": "ETS proto-oncogene 1, transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ets1"
      },
      {
        "slug": "fcgr2b",
        "symbol": "FCGR2B",
        "hgnc": "HGNC:3618",
        "name": "Fc gamma receptor IIb",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr2b"
      },
      {
        "slug": "fcgr3b",
        "symbol": "FCGR3B",
        "hgnc": "HGNC:3620",
        "name": "Fc gamma receptor IIIb",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr3b"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "ighg1",
        "symbol": "IGHG1",
        "hgnc": "HGNC:5525",
        "name": "immunoglobulin heavy constant gamma 1 (G1m marker)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighg1"
      },
      {
        "slug": "il10",
        "symbol": "IL10",
        "hgnc": "HGNC:5962",
        "name": "interleukin 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10"
      },
      {
        "slug": "irf5",
        "symbol": "IRF5",
        "hgnc": "HGNC:6120",
        "name": "interferon regulatory factor 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf5"
      },
      {
        "slug": "itgam",
        "symbol": "ITGAM",
        "hgnc": "HGNC:6149",
        "name": "integrin subunit alpha M",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgam"
      },
      {
        "slug": "jazf1",
        "symbol": "JAZF1",
        "hgnc": "HGNC:28917",
        "name": "JAZF zinc finger 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jazf1"
      },
      {
        "slug": "kiaa0319l",
        "symbol": "KIAA0319L",
        "hgnc": "HGNC:30071",
        "name": "KIAA0319 like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa0319l"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "pdcd1",
        "symbol": "PDCD1",
        "hgnc": "HGNC:8760",
        "name": "programmed cell death 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdcd1"
      },
      {
        "slug": "prkcd",
        "symbol": "PRKCD",
        "hgnc": "HGNC:9399",
        "name": "protein kinase C delta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkcd"
      },
      {
        "slug": "ptpn22",
        "symbol": "PTPN22",
        "hgnc": "HGNC:9652",
        "name": "protein tyrosine phosphatase non-receptor type 22",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn22"
      },
      {
        "slug": "pxk",
        "symbol": "PXK",
        "hgnc": "HGNC:23326",
        "name": "PX domain containing serine/threonine kinase like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pxk"
      },
      {
        "slug": "tlr7",
        "symbol": "TLR7",
        "hgnc": "HGNC:15631",
        "name": "toll like receptor 7",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tlr7"
      },
      {
        "slug": "tnfaip3",
        "symbol": "TNFAIP3",
        "hgnc": "HGNC:11896",
        "name": "TNF alpha induced protein 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfaip3"
      },
      {
        "slug": "tnfsf4",
        "symbol": "TNFSF4",
        "hgnc": "HGNC:11934",
        "name": "TNF superfamily member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfsf4"
      },
      {
        "slug": "tnip1",
        "symbol": "TNIP1",
        "hgnc": "HGNC:16903",
        "name": "TNFAIP3 interacting protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnip1"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trex1"
      },
      {
        "slug": "ube2l3",
        "symbol": "UBE2L3",
        "hgnc": "HGNC:12488",
        "name": "ubiquitin conjugating enzyme E2 L3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube2l3"
      }
    ]
  }
}