{
  "url": "https://dantelabs.com/traits/crypt-hyperplasia",
  "trait": {
    "bundleId": "2026.10.18-e609d43e",
    "release": "2026-09-01",
    "slug": "crypt-hyperplasia",
    "id": "HP:0034588",
    "name": "Crypt hyperplasia",
    "definition": "Crypt hyperplasia denotes elongation of the length of the crypts of Lieberkuhn, a process that initially precedes villous atrophy. Elongation may be caused by expansion of the lamina propria as a result of the proliferation of stromal cells, an influx of inflammatory cells and tissue remodeling.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-small-intestinal-mucosa-morphology",
        "name": "Abnormal small intestinal mucosa morphology",
        "url": "https://dantelabs.com/traits/abnormal-small-intestinal-mucosa-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "epcam",
        "symbol": "EPCAM",
        "hgnc": "HGNC:11529",
        "name": "epithelial cell adhesion molecule",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epcam"
      }
    ]
  }
}