{
  "url": "https://dantelabs.com/traits/coronal-craniosynostosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "coronal-craniosynostosis",
    "id": "HP:0004440",
    "name": "Coronal craniosynostosis",
    "definition": "Premature closure of the coronal suture of skull.",
    "synonyms": [
      "Coronal suture craniosynostosis",
      "Coronal suture synostosis",
      "Craniosynostosis of coronal suture"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "craniosynostosis",
        "name": "Deformity of the skull",
        "url": "https://dantelabs.com/traits/craniosynostosis"
      }
    ],
    "narrower": [
      {
        "slug": "bicoronal-synostosis",
        "name": "Bicoronal synostosis",
        "genes": 13,
        "url": "https://dantelabs.com/traits/bicoronal-synostosis"
      },
      {
        "slug": "unicoronal-synostosis",
        "name": "Unicoronal synostosis",
        "genes": 3,
        "url": "https://dantelabs.com/traits/unicoronal-synostosis"
      }
    ],
    "genes": [
      {
        "slug": "ahdc1",
        "symbol": "AHDC1",
        "hgnc": "HGNC:25230",
        "name": "AT-hook DNA binding motif containing 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ahdc1"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "frequency": "obligate",
        "diseases": 10,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "il11ra",
        "symbol": "IL11RA",
        "hgnc": "HGNC:5967",
        "name": "interleukin 11 receptor subunit alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il11ra"
      },
      {
        "slug": "p4hb",
        "symbol": "P4HB",
        "hgnc": "HGNC:8548",
        "name": "prolyl 4-hydroxylase subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/p4hb"
      },
      {
        "slug": "rnu12",
        "symbol": "RNU12",
        "hgnc": "HGNC:19380",
        "name": "RNA, U12 small nuclear",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rnu12"
      },
      {
        "slug": "slc25a24",
        "symbol": "SLC25A24",
        "hgnc": "HGNC:20662",
        "name": "solute carrier family 25 member 24",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc25a24"
      },
      {
        "slug": "alx4",
        "symbol": "ALX4",
        "hgnc": "HGNC:450",
        "name": "ALX homeobox 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alx4"
      },
      {
        "slug": "fgfr3",
        "symbol": "FGFR3",
        "hgnc": "HGNC:3690",
        "name": "fibroblast growth factor receptor 3",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/fgfr3"
      },
      {
        "slug": "sec24d",
        "symbol": "SEC24D",
        "hgnc": "HGNC:10706",
        "name": "SEC24 homolog D, COPII component",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec24d"
      },
      {
        "slug": "twist1",
        "symbol": "TWIST1",
        "hgnc": "HGNC:12428",
        "name": "twist family bHLH transcription factor 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/twist1"
      },
      {
        "slug": "erf",
        "symbol": "ERF",
        "hgnc": "HGNC:3444",
        "name": "ETS2 repressor factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erf"
      },
      {
        "slug": "specc1l",
        "symbol": "SPECC1L",
        "hgnc": "HGNC:29022",
        "name": "sperm antigen with calponin homology and coiled-coil domains 1 like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/specc1l"
      },
      {
        "slug": "bpnt2",
        "symbol": "BPNT2",
        "hgnc": "HGNC:26019",
        "name": "3'(2'), 5'-bisphosphate nucleotidase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bpnt2"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "pola1",
        "symbol": "POLA1",
        "hgnc": "HGNC:9173",
        "name": "DNA polymerase alpha 1, catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pola1"
      },
      {
        "slug": "recql4",
        "symbol": "RECQL4",
        "hgnc": "HGNC:9949",
        "name": "RecQ like helicase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/recql4"
      },
      {
        "slug": "tcof1",
        "symbol": "TCOF1",
        "hgnc": "HGNC:11654",
        "name": "treacle ribosome biogenesis factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcof1"
      },
      {
        "slug": "ctsk",
        "symbol": "CTSK",
        "hgnc": "HGNC:2536",
        "name": "cathepsin K",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsk"
      },
      {
        "slug": "ccbe1",
        "symbol": "CCBE1",
        "hgnc": "HGNC:29426",
        "name": "collagen and calcium binding EGF domains 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccbe1"
      },
      {
        "slug": "efnb1",
        "symbol": "EFNB1",
        "hgnc": "HGNC:3226",
        "name": "ephrin B1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efnb1"
      },
      {
        "slug": "gtf2e2",
        "symbol": "GTF2E2",
        "hgnc": "HGNC:4651",
        "name": "general transcription factor IIE subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf2e2"
      },
      {
        "slug": "masp1",
        "symbol": "MASP1",
        "hgnc": "HGNC:6901",
        "name": "MBL associated serine protease 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/masp1"
      },
      {
        "slug": "por",
        "symbol": "POR",
        "hgnc": "HGNC:9208",
        "name": "cytochrome p450 oxidoreductase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/por"
      },
      {
        "slug": "rab23",
        "symbol": "RAB23",
        "hgnc": "HGNC:14263",
        "name": "RAB23, member RAS oncogene family",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab23"
      }
    ]
  }
}