{
  "url": "https://dantelabs.com/traits/corneal-dystrophy",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "corneal-dystrophy",
    "id": "HP:0001131",
    "name": "Corneal dystrophy",
    "definition": "The term corneal dystrophy embraces a heterogenous group of bilateral genetically determined non-inflammatory corneal diseases that are restricted to the cornea.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cornea-morphology",
        "name": "Abnormal cornea morphology",
        "url": "https://dantelabs.com/traits/abnormal-cornea-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "band-shaped-corneal-dystrophy",
        "name": "Band-shaped corneal dystrophy",
        "genes": 2,
        "url": "https://dantelabs.com/traits/band-shaped-corneal-dystrophy"
      },
      {
        "slug": "lattice-corneal-dystrophy",
        "name": "Lattice corneal dystrophy",
        "genes": 2,
        "url": "https://dantelabs.com/traits/lattice-corneal-dystrophy"
      },
      {
        "slug": "granular-corneal-dystrophy",
        "name": "Granular corneal dystrophy",
        "genes": 1,
        "url": "https://dantelabs.com/traits/granular-corneal-dystrophy"
      },
      {
        "slug": "marginal-corneal-dystrophy",
        "name": "Marginal corneal dystrophy",
        "genes": 1,
        "url": "https://dantelabs.com/traits/marginal-corneal-dystrophy"
      },
      {
        "slug": "mosaic-corneal-dystrophy",
        "name": "Mosaic corneal dystrophy",
        "genes": 1,
        "url": "https://dantelabs.com/traits/mosaic-corneal-dystrophy"
      },
      {
        "slug": "punctate-corneal-dystrophy",
        "name": "Punctate corneal dystrophy",
        "genes": 1,
        "url": "https://dantelabs.com/traits/punctate-corneal-dystrophy"
      },
      {
        "slug": "speckled-corneal-dystrophy",
        "name": "Speckled corneal dystrophy",
        "genes": 1,
        "url": "https://dantelabs.com/traits/speckled-corneal-dystrophy"
      }
    ],
    "genes": [
      {
        "slug": "dcn",
        "symbol": "DCN",
        "hgnc": "HGNC:2705",
        "name": "decorin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dcn"
      },
      {
        "slug": "tgfbi",
        "symbol": "TGFBI",
        "hgnc": "HGNC:11771",
        "name": "transforming growth factor beta induced",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tgfbi"
      },
      {
        "slug": "zeb1",
        "symbol": "ZEB1",
        "hgnc": "HGNC:11642",
        "name": "zinc finger E-box binding homeobox 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zeb1"
      },
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "hgnc": "HGNC:2194",
        "name": "collagen type XVII alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col17a1"
      },
      {
        "slug": "gla",
        "symbol": "GLA",
        "hgnc": "HGNC:4296",
        "name": "galactosidase alpha",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gla"
      },
      {
        "slug": "mab21l1",
        "symbol": "MAB21L1",
        "hgnc": "HGNC:6757",
        "name": "mab-21 like 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mab21l1"
      },
      {
        "slug": "slc4a11",
        "symbol": "SLC4A11",
        "hgnc": "HGNC:16438",
        "name": "solute carrier family 4 member 11",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/slc4a11"
      },
      {
        "slug": "exosc2",
        "symbol": "EXOSC2",
        "hgnc": "HGNC:17097",
        "name": "exosome component 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/exosc2"
      },
      {
        "slug": "agk",
        "symbol": "AGK",
        "hgnc": "HGNC:21869",
        "name": "acylglycerol kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agk"
      },
      {
        "slug": "cryaa",
        "symbol": "CRYAA",
        "hgnc": "HGNC:2388",
        "name": "crystallin alpha A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cryaa"
      },
      {
        "slug": "cryba4",
        "symbol": "CRYBA4",
        "hgnc": "HGNC:2396",
        "name": "crystallin beta A4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cryba4"
      },
      {
        "slug": "crybb1",
        "symbol": "CRYBB1",
        "hgnc": "HGNC:2397",
        "name": "crystallin beta B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crybb1"
      },
      {
        "slug": "crybb2",
        "symbol": "CRYBB2",
        "hgnc": "HGNC:2398",
        "name": "crystallin beta B2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crybb2"
      },
      {
        "slug": "crygc",
        "symbol": "CRYGC",
        "hgnc": "HGNC:2410",
        "name": "crystallin gamma C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crygc"
      },
      {
        "slug": "crygd",
        "symbol": "CRYGD",
        "hgnc": "HGNC:2411",
        "name": "crystallin gamma D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crygd"
      },
      {
        "slug": "gja8",
        "symbol": "GJA8",
        "hgnc": "HGNC:4281",
        "name": "gap junction protein alpha 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja8"
      },
      {
        "slug": "gnaq",
        "symbol": "GNAQ",
        "hgnc": "HGNC:4390",
        "name": "G protein subunit alpha q",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnaq"
      },
      {
        "slug": "lrp1",
        "symbol": "LRP1",
        "hgnc": "HGNC:6692",
        "name": "LDL receptor related protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp1"
      },
      {
        "slug": "maf",
        "symbol": "MAF",
        "hgnc": "HGNC:6776",
        "name": "MAF bZIP transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/maf"
      },
      {
        "slug": "mbtps2",
        "symbol": "MBTPS2",
        "hgnc": "HGNC:15455",
        "name": "membrane bound transcription factor peptidase, site 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mbtps2"
      },
      {
        "slug": "opn1lw",
        "symbol": "OPN1LW",
        "hgnc": "HGNC:9936",
        "name": "opsin 1, long wave sensitive",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/opn1lw"
      },
      {
        "slug": "opn1mw",
        "symbol": "OPN1MW",
        "hgnc": "HGNC:4206",
        "name": "opsin 1, medium wave sensitive",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/opn1mw"
      },
      {
        "slug": "sat1",
        "symbol": "SAT1",
        "hgnc": "HGNC:10540",
        "name": "spermidine/spermine N1-acetyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sat1"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "tkfc",
        "symbol": "TKFC",
        "hgnc": "HGNC:24552",
        "name": "triokinase and FMN cyclase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tkfc"
      },
      {
        "slug": "trim37",
        "symbol": "TRIM37",
        "hgnc": "HGNC:7523",
        "name": "tripartite motif containing 37",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trim37"
      },
      {
        "slug": "col4a3",
        "symbol": "COL4A3",
        "hgnc": "HGNC:2204",
        "name": "collagen type IV alpha 3 chain",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a3"
      },
      {
        "slug": "col4a4",
        "symbol": "COL4A4",
        "hgnc": "HGNC:2206",
        "name": "collagen type IV alpha 4 chain",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a4"
      },
      {
        "slug": "agbl1",
        "symbol": "AGBL1",
        "hgnc": "HGNC:26504",
        "name": "AGBL carboxypeptidase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agbl1"
      },
      {
        "slug": "chst6",
        "symbol": "CHST6",
        "hgnc": "HGNC:6938",
        "name": "carbohydrate sulfotransferase 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chst6"
      },
      {
        "slug": "col8a2",
        "symbol": "COL8A2",
        "hgnc": "HGNC:2216",
        "name": "collagen type VIII alpha 2 chain",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col8a2"
      },
      {
        "slug": "krt12",
        "symbol": "KRT12",
        "hgnc": "HGNC:6414",
        "name": "keratin 12",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt12"
      },
      {
        "slug": "tacstd2",
        "symbol": "TACSTD2",
        "hgnc": "HGNC:11530",
        "name": "tumor associated calcium signal transducer 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tacstd2"
      }
    ]
  }
}