{
  "url": "https://dantelabs.com/traits/corneal-arcus",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "corneal-arcus",
    "id": "HP:0001084",
    "name": "Corneal arcus",
    "definition": "A hazy, grayish-white ring about 2 mm in width located close to but separated from the limbus (the corneoscleral junction). Corneal arcus generally occurs bilaterally, and is related to lipid deposition in the cornea. Corneal arcus can occur in elderly persons as a part of the aging process but may be associated with hypercholesterolemia in people under the age of 50 years.",
    "synonyms": [
      "Anterior embryotoxon",
      "Arcus lipoidis",
      "Arcus senilis",
      "Corneal annulus",
      "Gerontoxon"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "peripheral-opacification-of-the-cornea",
        "name": "Peripheral opacification of the cornea",
        "url": "https://dantelabs.com/traits/peripheral-opacification-of-the-cornea"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "abcg8",
        "symbol": "ABCG8",
        "hgnc": "HGNC:13887",
        "name": "ATP binding cassette subfamily G member 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcg8"
      },
      {
        "slug": "lcat",
        "symbol": "LCAT",
        "hgnc": "HGNC:6522",
        "name": "lecithin-cholesterol acyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lcat"
      },
      {
        "slug": "apoe",
        "symbol": "APOE",
        "hgnc": "HGNC:613",
        "name": "apolipoprotein E",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apoe"
      },
      {
        "slug": "chrdl1",
        "symbol": "CHRDL1",
        "hgnc": "HGNC:29861",
        "name": "chordin like 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrdl1"
      },
      {
        "slug": "lipc",
        "symbol": "LIPC",
        "hgnc": "HGNC:6619",
        "name": "lipase C, hepatic type",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipc"
      },
      {
        "slug": "slc29a3",
        "symbol": "SLC29A3",
        "hgnc": "HGNC:23096",
        "name": "solute carrier family 29 member 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc29a3"
      },
      {
        "slug": "apoa1",
        "symbol": "APOA1",
        "hgnc": "HGNC:600",
        "name": "apolipoprotein A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apoa1"
      },
      {
        "slug": "aldh18a1",
        "symbol": "ALDH18A1",
        "hgnc": "HGNC:9722",
        "name": "aldehyde dehydrogenase 18 family member A1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh18a1"
      },
      {
        "slug": "apoa2",
        "symbol": "APOA2",
        "hgnc": "HGNC:601",
        "name": "apolipoprotein A2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apoa2"
      },
      {
        "slug": "apob",
        "symbol": "APOB",
        "hgnc": "HGNC:603",
        "name": "apolipoprotein B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apob"
      },
      {
        "slug": "ephx2",
        "symbol": "EPHX2",
        "hgnc": "HGNC:3402",
        "name": "epoxide hydrolase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ephx2"
      },
      {
        "slug": "ghr",
        "symbol": "GHR",
        "hgnc": "HGNC:4263",
        "name": "growth hormone receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ghr"
      },
      {
        "slug": "kera",
        "symbol": "KERA",
        "hgnc": "HGNC:6309",
        "name": "keratocan",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kera"
      },
      {
        "slug": "ldlr",
        "symbol": "LDLR",
        "hgnc": "HGNC:6547",
        "name": "low density lipoprotein receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldlr"
      },
      {
        "slug": "pcsk9",
        "symbol": "PCSK9",
        "hgnc": "HGNC:20001",
        "name": "proprotein convertase subtilisin/kexin type 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcsk9"
      },
      {
        "slug": "ppp1r17",
        "symbol": "PPP1R17",
        "hgnc": "HGNC:16973",
        "name": "protein phosphatase 1 regulatory subunit 17",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp1r17"
      },
      {
        "slug": "ubiad1",
        "symbol": "UBIAD1",
        "hgnc": "HGNC:30791",
        "name": "UbiA prenyltransferase domain containing 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubiad1"
      }
    ]
  }
}