{
  "url": "https://dantelabs.com/traits/coldness",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "coldness",
    "id": "HP:0033850",
    "name": "Coldness",
    "definition": "Relative coldness of a body part to palpitation, often acccompanied by feelings of coldness.",
    "synonyms": [
      "Cold skin temperature",
      "Cool skin",
      "Cool skin temperature",
      "Coolness to palpation"
    ],
    "systems": [
      {
        "slug": "constitutional-symptom",
        "name": "Constitutional symptom",
        "url": "https://dantelabs.com/traits/constitutional-symptom"
      }
    ],
    "broader": [
      {
        "slug": "constitutional-symptom",
        "name": "Constitutional symptom",
        "url": "https://dantelabs.com/traits/constitutional-symptom"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cdkl5",
        "symbol": "CDKL5",
        "hgnc": "HGNC:11411",
        "name": "cyclin dependent kinase like 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkl5"
      },
      {
        "slug": "foxe1",
        "symbol": "FOXE1",
        "hgnc": "HGNC:3806",
        "name": "forkhead box E1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxe1"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "nkx2-1",
        "symbol": "NKX2-1",
        "hgnc": "HGNC:11825",
        "name": "NK2 homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-1"
      },
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "hgnc": "HGNC:2488",
        "name": "NK2 homeobox 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-5"
      },
      {
        "slug": "pax8",
        "symbol": "PAX8",
        "hgnc": "HGNC:8622",
        "name": "paired box 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax8"
      },
      {
        "slug": "slc26a4",
        "symbol": "SLC26A4",
        "hgnc": "HGNC:8818",
        "name": "solute carrier family 26 member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a4"
      },
      {
        "slug": "tshr",
        "symbol": "TSHR",
        "hgnc": "HGNC:12373",
        "name": "thyroid stimulating hormone receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshr"
      }
    ]
  }
}