{
  "url": "https://dantelabs.com/traits/cognitive-regression",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "cognitive-regression",
    "id": "HP:0034332",
    "name": "Cognitive regression",
    "definition": "Loss of cognitive developmental skills, as manifested by loss of developmental cognitive milestones.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "developmental-regression",
        "name": "Loss of developmental milestones",
        "url": "https://dantelabs.com/traits/developmental-regression"
      }
    ],
    "narrower": [
      {
        "slug": "loss-of-acquired-spoken-language",
        "name": "Loss of acquired spoken language",
        "genes": 2,
        "url": "https://dantelabs.com/traits/loss-of-acquired-spoken-language"
      }
    ],
    "genes": [
      {
        "slug": "caprin1",
        "symbol": "CAPRIN1",
        "hgnc": "HGNC:6743",
        "name": "cell cycle associated protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/caprin1"
      },
      {
        "slug": "eprs1",
        "symbol": "EPRS1",
        "hgnc": "HGNC:3418",
        "name": "glutamyl-prolyl-tRNA synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eprs1"
      },
      {
        "slug": "snapc4",
        "symbol": "SNAPC4",
        "hgnc": "HGNC:11137",
        "name": "small nuclear RNA activating complex polypeptide 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snapc4"
      },
      {
        "slug": "mark2",
        "symbol": "MARK2",
        "hgnc": "HGNC:3332",
        "name": "microtubule affinity regulating kinase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mark2"
      },
      {
        "slug": "ttc19",
        "symbol": "TTC19",
        "hgnc": "HGNC:26006",
        "name": "tetratricopeptide repeat domain 19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc19"
      }
    ]
  }
}