{
  "url": "https://dantelabs.com/traits/chronotropic-incompetence",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "chronotropic-incompetence",
    "id": "HP:0033992",
    "name": "Chronotropic incompetence",
    "definition": "Inability of the heart to increase its rate commensurate with increased activity or demand.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cardiovascular-system-physiology",
        "name": "Abnormal cardiovascular system physiology",
        "url": "https://dantelabs.com/traits/abnormal-cardiovascular-system-physiology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "hcn4",
        "symbol": "HCN4",
        "hgnc": "HGNC:16882",
        "name": "hyperpolarization activated cyclic nucleotide gated potassium channel 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hcn4"
      },
      {
        "slug": "gnb2",
        "symbol": "GNB2",
        "hgnc": "HGNC:4398",
        "name": "G protein subunit beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnb2"
      }
    ]
  }
}