{
  "url": "https://dantelabs.com/traits/broad-metacarpals",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "broad-metacarpals",
    "id": "HP:0001230",
    "name": "Wide long bones of hand",
    "label": "Broad metacarpals",
    "definition": "Abnormally broad metacarpal bones.",
    "synonyms": [
      "Wide metacarpals"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-metacarpal-morphology",
        "name": "Abnormal shape of long bones of hand",
        "url": "https://dantelabs.com/traits/abnormal-metacarpal-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "broad-1st-metacarpal",
        "name": "Wide 1st long bone of hand",
        "genes": 1,
        "url": "https://dantelabs.com/traits/broad-1st-metacarpal"
      }
    ],
    "genes": [
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "mmp2",
        "symbol": "MMP2",
        "hgnc": "HGNC:7166",
        "name": "matrix metallopeptidase 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mmp2"
      },
      {
        "slug": "pde4d",
        "symbol": "PDE4D",
        "hgnc": "HGNC:8783",
        "name": "phosphodiesterase 4D",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde4d"
      },
      {
        "slug": "extl3",
        "symbol": "EXTL3",
        "hgnc": "HGNC:3518",
        "name": "exostosin like glycosyltransferase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/extl3"
      },
      {
        "slug": "mmp14",
        "symbol": "MMP14",
        "hgnc": "HGNC:7160",
        "name": "matrix metallopeptidase 14",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp14"
      },
      {
        "slug": "slc26a2",
        "symbol": "SLC26A2",
        "hgnc": "HGNC:10994",
        "name": "solute carrier family 26 member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a2"
      },
      {
        "slug": "tfe3",
        "symbol": "TFE3",
        "hgnc": "HGNC:11752",
        "name": "transcription factor binding to IGHM enhancer 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfe3"
      },
      {
        "slug": "bmpr1b",
        "symbol": "BMPR1B",
        "hgnc": "HGNC:1077",
        "name": "bone morphogenetic protein receptor type 1B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1b"
      },
      {
        "slug": "gdf5",
        "symbol": "GDF5",
        "hgnc": "HGNC:4220",
        "name": "growth differentiation factor 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf5"
      },
      {
        "slug": "glb1",
        "symbol": "GLB1",
        "hgnc": "HGNC:4298",
        "name": "galactosidase beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glb1"
      },
      {
        "slug": "ihh",
        "symbol": "IHH",
        "hgnc": "HGNC:5956",
        "name": "Indian hedgehog signaling molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ihh"
      },
      {
        "slug": "adamts10",
        "symbol": "ADAMTS10",
        "hgnc": "HGNC:13201",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts10"
      },
      {
        "slug": "bgn",
        "symbol": "BGN",
        "hgnc": "HGNC:1044",
        "name": "biglycan",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bgn"
      },
      {
        "slug": "ddr2",
        "symbol": "DDR2",
        "hgnc": "HGNC:2731",
        "name": "discoidin domain receptor tyrosine kinase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddr2"
      },
      {
        "slug": "dnmt3a",
        "symbol": "DNMT3A",
        "hgnc": "HGNC:2978",
        "name": "DNA methyltransferase 3 alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt3a"
      },
      {
        "slug": "fbn1",
        "symbol": "FBN1",
        "hgnc": "HGNC:3603",
        "name": "fibrillin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbn1"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "npr2",
        "symbol": "NPR2",
        "hgnc": "HGNC:7944",
        "name": "natriuretic peptide receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npr2"
      }
    ]
  }
}