{
  "url": "https://dantelabs.com/traits/acute-phase-response",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "acute-phase-response",
    "id": "HP:0033331",
    "name": "Acute phase response",
    "definition": "Presence of one or more manifestations of the acute phase response. Acute phase proteins (APP) are blood proteins primarily synthesized by hepatocytes as part of the acute phase response (APR). The APR is part of the early-defense or innate immune system, which is triggered by different stimuli including trauma, infection, stress, neoplasia, and inflammation. The APR results in a complex systemic reaction with the goal of reestablishing homeostasis and promoting healing.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "narrower": [
      {
        "slug": "elevated-circulating-c-reactive-protein-concentration",
        "name": "Elevated circulating C-reactive protein concentration",
        "genes": 90,
        "url": "https://dantelabs.com/traits/elevated-circulating-c-reactive-protein-concentration"
      },
      {
        "slug": "elevated-erythrocyte-sedimentation-rate",
        "name": "High ESR",
        "genes": 80,
        "url": "https://dantelabs.com/traits/elevated-erythrocyte-sedimentation-rate"
      },
      {
        "slug": "increased-circulating-ferritin-concentration",
        "name": "Elevated serum ferritin",
        "genes": 57,
        "url": "https://dantelabs.com/traits/increased-circulating-ferritin-concentration"
      },
      {
        "slug": "abnormal-circulating-calcium-phosphate-regulating-hormone-concentration",
        "name": "Abnormal circulating calcium-phosphate regulating hormone concentration",
        "genes": 7,
        "url": "https://dantelabs.com/traits/abnormal-circulating-calcium-phosphate-regulating-hormone-concentration"
      },
      {
        "slug": "elevated-circulating-hepcidin-concentration",
        "name": "Elevated circulating hepcidin concentration",
        "genes": 3,
        "url": "https://dantelabs.com/traits/elevated-circulating-hepcidin-concentration"
      },
      {
        "slug": "elevated-circulating-serum-amyloid-a-concentration",
        "name": "Elevated circulating serum amyloid A concentration",
        "genes": 2,
        "url": "https://dantelabs.com/traits/elevated-circulating-serum-amyloid-a-concentration"
      }
    ],
    "genes": [
      {
        "slug": "psmg2",
        "symbol": "PSMG2",
        "hgnc": "HGNC:24929",
        "name": "proteasome assembly chaperone 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmg2"
      },
      {
        "slug": "prg4",
        "symbol": "PRG4",
        "hgnc": "HGNC:9364",
        "name": "proteoglycan 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prg4"
      }
    ]
  }
}