{
  "url": "https://dantelabs.com/traits/acral-ulceration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "acral-ulceration",
    "id": "HP:0006121",
    "name": "Acral ulceration",
    "definition": "A type of digital ulcer that manifests as an open sore on the surface of the skin at the tip of a finger or toe.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "digital-ulcer",
        "name": "Digital ulcer",
        "url": "https://dantelabs.com/traits/digital-ulcer"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "kif1a",
        "symbol": "KIF1A",
        "hgnc": "HGNC:888",
        "name": "kinesin family member 1A",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kif1a"
      },
      {
        "slug": "retreg1",
        "symbol": "RETREG1",
        "hgnc": "HGNC:25964",
        "name": "reticulophagy regulator 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/retreg1"
      },
      {
        "slug": "cct5",
        "symbol": "CCT5",
        "hgnc": "HGNC:1618",
        "name": "chaperonin containing TCP1 subunit 5",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cct5"
      },
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpv17"
      },
      {
        "slug": "ngf",
        "symbol": "NGF",
        "hgnc": "HGNC:7808",
        "name": "nerve growth factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ngf"
      },
      {
        "slug": "ntrk1",
        "symbol": "NTRK1",
        "hgnc": "HGNC:8031",
        "name": "neurotrophic receptor tyrosine kinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ntrk1"
      },
      {
        "slug": "scn9a",
        "symbol": "SCN9A",
        "hgnc": "HGNC:10597",
        "name": "sodium voltage-gated channel alpha subunit 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn9a"
      },
      {
        "slug": "sptlc1",
        "symbol": "SPTLC1",
        "hgnc": "HGNC:11277",
        "name": "serine palmitoyltransferase long chain base subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc1"
      },
      {
        "slug": "wnk1",
        "symbol": "WNK1",
        "hgnc": "HGNC:14540",
        "name": "WNK lysine deficient protein kinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnk1"
      }
    ]
  }
}