{
  "url": "https://dantelabs.com/traits/abnormal-lung-morphology",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "abnormal-lung-morphology",
    "id": "HP:0002088",
    "name": "Abnormality of lung structure",
    "label": "Abnormal lung morphology",
    "definition": "Any structural anomaly of the lung.",
    "synonyms": [
      "Abnormality of the lungs",
      "Abnormally shaped lung",
      "Lung disease",
      "Unusual lung shape"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-respiratory-system-morphology",
        "name": "Abnormal respiratory system morphology",
        "url": "https://dantelabs.com/traits/abnormal-respiratory-system-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "respiratory-tract-infection",
        "name": "Respiratory tract infection",
        "genes": 119,
        "url": "https://dantelabs.com/traits/respiratory-tract-infection"
      },
      {
        "slug": "emphysema",
        "name": "Emphysema",
        "genes": 43,
        "url": "https://dantelabs.com/traits/emphysema"
      },
      {
        "slug": "abnormal-pulmonary-interstitial-morphology",
        "name": "Abnormality in area between air sacs in lung",
        "genes": 39,
        "url": "https://dantelabs.com/traits/abnormal-pulmonary-interstitial-morphology"
      },
      {
        "slug": "neoplasm-of-the-lung",
        "name": "Lung cancer",
        "genes": 31,
        "url": "https://dantelabs.com/traits/neoplasm-of-the-lung"
      },
      {
        "slug": "pulmonary-edema",
        "name": "Excess fluid in lungs",
        "genes": 30,
        "url": "https://dantelabs.com/traits/pulmonary-edema"
      },
      {
        "slug": "abnormal-pleura-morphology",
        "name": "Abnormal pleura morphology",
        "genes": 14,
        "url": "https://dantelabs.com/traits/abnormal-pleura-morphology"
      },
      {
        "slug": "pulmonary-hemorrhage",
        "name": "Pulmonary hemorrhage",
        "genes": 8,
        "url": "https://dantelabs.com/traits/pulmonary-hemorrhage"
      },
      {
        "slug": "pulmonary-cyst",
        "name": "Pulmonary cyst",
        "genes": 3,
        "url": "https://dantelabs.com/traits/pulmonary-cyst"
      },
      {
        "slug": "pulmonary-hyperplasia",
        "name": "Pulmonary hyperplasia",
        "genes": 2,
        "url": "https://dantelabs.com/traits/pulmonary-hyperplasia"
      },
      {
        "slug": "abnormality-of-the-pulmonary-vasculature",
        "name": "Abnormality of the lung blood vessels",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormality-of-the-pulmonary-vasculature"
      },
      {
        "slug": "abnormal-bronchoalveolar-lavage-fluid-morphology",
        "name": "Abnormal bronchoalveolar lavage fluid morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-bronchoalveolar-lavage-fluid-morphology"
      },
      {
        "slug": "abnormal-lung-development",
        "name": "Abnormal lung development",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-lung-development"
      },
      {
        "slug": "abnormal-pulmonary-alveolar-system-morphology",
        "name": "Abnormal pulmonary alveolar system morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-pulmonary-alveolar-system-morphology"
      },
      {
        "slug": "abnormal-pulmonary-lymphatics",
        "name": "Abnormal pulmonary lymphatics",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-pulmonary-lymphatics"
      },
      {
        "slug": "abnormal-subpleural-morphology",
        "name": "Abnormal subpleural morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-subpleural-morphology"
      }
    ],
    "genes": [
      {
        "slug": "btk",
        "symbol": "BTK",
        "hgnc": "HGNC:1133",
        "name": "Bruton tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btk"
      },
      {
        "slug": "btnl2",
        "symbol": "BTNL2",
        "hgnc": "HGNC:1142",
        "name": "butyrophilin like 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btnl2"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "stra6",
        "symbol": "STRA6",
        "hgnc": "HGNC:30650",
        "name": "signaling receptor and transporter of retinol STRA6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stra6"
      },
      {
        "slug": "wnt7b",
        "symbol": "WNT7B",
        "hgnc": "HGNC:12787",
        "name": "Wnt family member 7B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt7b"
      },
      {
        "slug": "bap1",
        "symbol": "BAP1",
        "hgnc": "HGNC:950",
        "name": "BRCA1 associated deubiquitinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bap1"
      },
      {
        "slug": "ebp",
        "symbol": "EBP",
        "hgnc": "HGNC:3133",
        "name": "EBP cholestenol delta-isomerase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebp"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "cyp27a1",
        "symbol": "CYP27A1",
        "hgnc": "HGNC:2605",
        "name": "cytochrome P450 family 27 subfamily A member 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp27a1"
      }
    ]
  }
}