{
  "url": "https://dantelabs.com/traits/abnormal-diminished-volition",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-diminished-volition",
    "id": "HP:0000745",
    "name": "Diminished motivation",
    "label": "Abnormal diminished volition",
    "definition": "A reduction in willful and motivated goal-directed behavior that is considered the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action.",
    "synonyms": [
      "Lack of initiative",
      "Lack of motivation",
      "Lacking in initiative",
      "Lacks initiative",
      "Diminished energy",
      "Diminished volitional state"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-volitional-state",
        "name": "Abnormal volitional state",
        "url": "https://dantelabs.com/traits/abnormal-volitional-state"
      }
    ],
    "narrower": [
      {
        "slug": "depression",
        "name": "Depression",
        "genes": 464,
        "url": "https://dantelabs.com/traits/depression"
      },
      {
        "slug": "lethargy",
        "name": "Lethargy",
        "genes": 262,
        "url": "https://dantelabs.com/traits/lethargy"
      },
      {
        "slug": "apathy",
        "name": "Lack of feeling, emotion, interest",
        "genes": 94,
        "url": "https://dantelabs.com/traits/apathy"
      },
      {
        "slug": "abulia",
        "name": "Abulia",
        "genes": 10,
        "url": "https://dantelabs.com/traits/abulia"
      },
      {
        "slug": "negativism",
        "name": "Negativism",
        "genes": 9,
        "url": "https://dantelabs.com/traits/negativism"
      },
      {
        "slug": "inertia",
        "name": "Inertia",
        "genes": 5,
        "url": "https://dantelabs.com/traits/inertia"
      },
      {
        "slug": "akinetic-mutism",
        "name": "Akinetic mutism",
        "genes": 4,
        "url": "https://dantelabs.com/traits/akinetic-mutism"
      },
      {
        "slug": "self-neglect",
        "name": "Self-neglect",
        "genes": 1,
        "url": "https://dantelabs.com/traits/self-neglect"
      }
    ],
    "genes": [
      {
        "slug": "ttc19",
        "symbol": "TTC19",
        "hgnc": "HGNC:26006",
        "name": "tetratricopeptide repeat domain 19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc19"
      },
      {
        "slug": "mapt",
        "symbol": "MAPT",
        "hgnc": "HGNC:6893",
        "name": "microtubule associated protein tau",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mapt"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/psen1"
      }
    ]
  }
}