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      ],
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      {
        "slug": "monogenic-hypertension-mineralocorticoid-disorders",
        "name": "Hipertensión monogénica y trastornos de los mineralocorticoides",
        "diseases": [
          {
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            "name": "Pseudohipoaldosteronismo tipo 2 (síndrome de Gordon)",
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            "inheritance": "autosomal-dominant",
            "description": "Una afección causada por cambios en WNK1, WNK4, KLHL3 o CUL3 que provoca hipertensión arterial con potasio alto y acumulación de ácido en la sangre.",
            "management": "Conocerlo orienta hacia los diuréticos tiazídicos, que por lo general corrigen tanto la presión arterial como el potasio.",
            "evidence": {
              "gencc": [
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                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
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              "clingen": "Definitive",
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              "inheritance": [
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        ],
        "url": "https://dantelabs.com/es/conditions/monogenic-hypertension-mineralocorticoid-disorders"
      }
    ],
    "pharmacogenomics": [],
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        "name": "High blood pressure",
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        "url": "https://dantelabs.com/traits/hypertension"
      },
      {
        "slug": "hyperchloremia",
        "name": "Hyperchloremia",
        "systems": [
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        "url": "https://dantelabs.com/traits/hyperchloremia"
      },
      {
        "slug": "hyperchloremic-metabolic-acidosis",
        "name": "Hyperchloremic metabolic acidosis",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/hyperchloremic-metabolic-acidosis"
      },
      {
        "slug": "hyperkalemia",
        "name": "Increased circulating potassium concentration",
        "systems": [
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        "url": "https://dantelabs.com/traits/hyperkalemia"
      },
      {
        "slug": "pseudohypoaldosteronism",
        "name": "Pseudohypoaldosteronism",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/pseudohypoaldosteronism"
      }
    ],
    "related": [
      {
        "slug": "cul3",
        "symbol": "CUL3",
        "name": "cullin 3",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/cul3"
      },
      {
        "slug": "klhl3",
        "symbol": "KLHL3",
        "name": "kelch like family member 3",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/klhl3"
      },
      {
        "slug": "wnk1",
        "symbol": "WNK1",
        "name": "WNK lysine deficient protein kinase 1",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/wnk1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}