{
  "url": "https://dantelabs.com/es/genes/rpl21",
  "gene": {
    "slug": "rpl21",
    "symbol": "RPL21",
    "name": "ribosomal protein L21",
    "hgnc": "HGNC:10313",
    "summary": null,
    "location": "13q12.2",
    "locusType": "gene with protein product",
    "aliases": [
      "L21",
      "FLJ27458",
      "MGC71252",
      "MGC104274",
      "MGC104275",
      "DKFZp686C06101",
      "eL21"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000122026",
    "entrezId": 6144,
    "omim": [
      "603636"
    ],
    "uniprot": [
      "P46778"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "13",
      "start": 27251558,
      "end": 27256568,
      "strand": "+",
      "ensemblTranscript": "ENST00000311549.11",
      "refseqTranscript": "NM_000982.4",
      "ensemblProtein": "ENSP00000346027.4",
      "refseqProtein": "NP_000973.2",
      "exons": [
        {
          "start": 27251558,
          "end": 27251585
        },
        {
          "start": 27253765,
          "end": 27253843
        },
        {
          "start": 27254220,
          "end": 27254281
        },
        {
          "start": 27255242,
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        },
        {
          "start": 27256184,
          "end": 27256334
        },
        {
          "start": 27256436,
          "end": 27256568
        }
      ],
      "cds": {
        "start": 27253777,
        "end": 27256525
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "13",
      "start": 27825446,
      "end": 27830828,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 26754063,
      "end": 27754062,
      "genes": [
        {
          "symbol": "GPR12",
          "ensemblId": "ENSG00000132975",
          "biotype": "protein_coding",
          "start": 26755200,
          "end": 26761028,
          "strand": "-",
          "slug": "gpr12"
        },
        {
          "symbol": "USP12",
          "ensemblId": "ENSG00000152484",
          "biotype": "protein_coding",
          "start": 27066146,
          "end": 27171885,
          "strand": "-",
          "slug": "usp12"
        },
        {
          "symbol": "RASL11A",
          "ensemblId": "ENSG00000122035",
          "biotype": "protein_coding",
          "start": 27270786,
          "end": 27275192,
          "strand": "+",
          "slug": "rasl11a"
        },
        {
          "symbol": "GTF3A",
          "ensemblId": "ENSG00000122034",
          "biotype": "protein_coding",
          "start": 27424584,
          "end": 27435823,
          "strand": "+",
          "slug": "gtf3a"
        },
        {
          "symbol": "MTIF3",
          "ensemblId": "ENSG00000122033",
          "biotype": "protein_coding",
          "start": 27429823,
          "end": 27450613,
          "strand": "-",
          "slug": "mtif3"
        },
        {
          "symbol": "LNX2",
          "ensemblId": "ENSG00000139517",
          "biotype": "protein_coding",
          "start": 27545911,
          "end": 27621354,
          "strand": "-",
          "slug": "lnx2"
        },
        {
          "symbol": "POLR1D",
          "ensemblId": "ENSG00000186184",
          "biotype": "protein_coding",
          "start": 27620742,
          "end": 27744237,
          "strand": "+",
          "slug": "polr1d"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-hypotrichosis-and-hair-shaft-disorders",
        "name": "Hipotricosis hereditaria, cabello lanoso y monilethrix",
        "diseases": [
          {
            "mondoId": "MONDO:0003037",
            "name": "Hipotricosis hereditaria",
            "genes": 11,
            "inheritance": null,
            "description": "Cabello del cuero cabelludo y del cuerpo escaso o ausente desde la infancia, incluidas las formas relacionadas con LIPH y LPAR6.",
            "management": null,
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/es/conditions/hereditary-hypotrichosis-and-hair-shaft-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "dry-hair",
        "name": "Dry hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dry-hair"
      },
      {
        "slug": "alopecia",
        "name": "Hair loss",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/alopecia"
      },
      {
        "slug": "sparse-axillary-hair",
        "name": "Limited armpit hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-axillary-hair"
      },
      {
        "slug": "slow-growing-hair",
        "name": "Slow-growing hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/slow-growing-hair"
      },
      {
        "slug": "sparse-body-hair",
        "name": "Sparse body hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-body-hair"
      },
      {
        "slug": "sparse-eyebrow",
        "name": "Sparse eyebrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-eyebrow"
      },
      {
        "slug": "sparse-eyelashes",
        "name": "Sparse eyelashes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-eyelashes"
      },
      {
        "slug": "sparse-hair",
        "name": "Sparse hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sparse-hair"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-eyebrow",
        "name": "Sparse or absent eyebrows",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-eyebrow"
      },
      {
        "slug": "sparse-or-absent-eyelashes",
        "name": "Sparse or absent eyelashes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-or-absent-eyelashes"
      },
      {
        "slug": "sparse-pubic-hair",
        "name": "Sparse pubic hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-pubic-hair"
      },
      {
        "slug": "sparse-scalp-hair",
        "name": "Sparse scalp hair",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sparse-scalp-hair"
      }
    ],
    "related": [
      {
        "slug": "apcdd1",
        "symbol": "APCDD1",
        "name": "APC down-regulated 1",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/apcdd1"
      },
      {
        "slug": "c3orf52",
        "symbol": "C3orf52",
        "name": "chromosome 3 open reading frame 52",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/c3orf52"
      },
      {
        "slug": "cdh3",
        "symbol": "CDH3",
        "name": "cadherin 3",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/cdh3"
      },
      {
        "slug": "cdsn",
        "symbol": "CDSN",
        "name": "corneodesmosin",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/cdsn"
      },
      {
        "slug": "dsg4",
        "symbol": "DSG4",
        "name": "desmoglein 4",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/dsg4"
      },
      {
        "slug": "hr",
        "symbol": "HR",
        "name": "HR lysine demethylase and nuclear receptor corepressor",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/hr"
      },
      {
        "slug": "liph",
        "symbol": "LIPH",
        "name": "lipase H",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/liph"
      },
      {
        "slug": "lpar6",
        "symbol": "LPAR6",
        "name": "lysophosphatidic acid receptor 6",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/lpar6"
      },
      {
        "slug": "lss",
        "symbol": "LSS",
        "name": "lanosterol synthase",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/lss"
      },
      {
        "slug": "snrpe",
        "symbol": "SNRPE",
        "name": "small nuclear ribonucleoprotein polypeptide E",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/snrpe"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}