{
  "url": "https://dantelabs.com/es/genes/mcm8",
  "gene": {
    "slug": "mcm8",
    "symbol": "MCM8",
    "name": "minichromosome maintenance 8 homologous recombination repair factor",
    "hgnc": "HGNC:16147",
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    "aliases": [
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      "MGC12866",
      "MGC119522",
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      "REC"
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    "previousSymbols": [
      "C20orf154"
    ],
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    "entrezId": 84515,
    "omim": [
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    "uniprot": [
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      "ensemblTranscript": "ENST00000610722.4",
      "refseqTranscript": "NM_032485.6",
      "ensemblProtein": "ENSP00000478141.1",
      "refseqProtein": "NP_115874.3",
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    },
    "grch37": {
      "build": "GRCh37",
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      "chrom": "20",
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    },
    "neighbourhood": {
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        {
          "symbol": "GPCPD1",
          "ensemblId": "ENSG00000125772",
          "biotype": "protein_coding",
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          "end": 5611058,
          "strand": "-",
          "slug": "gpcpd1"
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        {
          "symbol": "SHLD1",
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        {
          "symbol": "CHGB",
          "ensemblId": "ENSG00000089199",
          "biotype": "protein_coding",
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          "end": 5925940,
          "strand": "+",
          "slug": "chgb"
        },
        {
          "symbol": "TRMT6",
          "ensemblId": "ENSG00000089195",
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          "strand": "-",
          "slug": "trmt6"
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        {
          "symbol": "",
          "ensemblId": "ENSG00000286235",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "CRLS1",
          "ensemblId": "ENSG00000088766",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "crls1"
        },
        {
          "symbol": "LRRN4",
          "ensemblId": "ENSG00000125872",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "lrrn4"
        },
        {
          "symbol": "FERMT1",
          "ensemblId": "ENSG00000101311",
          "biotype": "protein_coding",
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          "end": 6123644,
          "strand": "-",
          "slug": "fermt1"
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "female-infertility",
        "name": "Infertilidad femenina",
        "diseases": [
          {
            "mondoId": "MONDO:0021124",
            "name": "Infertilidad femenina",
            "genes": 37,
            "inheritance": null,
            "description": "Capacidad disminuida o ausente de una mujer para lograr la concepción.",
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/es/conditions/female-infertility"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "azoospermia",
        "name": "Absent sperm in semen",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/azoospermia"
      },
      {
        "slug": "decreased-testicular-size",
        "name": "Decreased testicular size",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/decreased-testicular-size"
      },
      {
        "slug": "premature-ovarian-insufficiency",
        "name": "Early menopause",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/premature-ovarian-insufficiency"
      },
      {
        "slug": "elevated-circulating-follicle-stimulating-hormone-level",
        "name": "Elevated circulating follicle stimulating hormone level",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/elevated-circulating-follicle-stimulating-hormone-level"
      },
      {
        "slug": "elevated-circulating-luteinizing-hormone-level",
        "name": "Elevated circulating luteinizing hormone level",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/elevated-circulating-luteinizing-hormone-level"
      },
      {
        "slug": "primary-amenorrhea",
        "name": "Primary amenorrhea",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/primary-amenorrhea"
      },
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/hypothyroidism"
      },
      {
        "slug": "hypoplasia-of-the-ovary",
        "name": "Underdeveloped ovary",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-ovary"
      }
    ],
    "related": [
      {
        "slug": "ankrd31",
        "symbol": "ANKRD31",
        "name": "ankyrin repeat domain 31",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/ankrd31"
      },
      {
        "slug": "atm",
        "symbol": "ATM",
        "name": "ATM serine/threonine kinase",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/atm"
      },
      {
        "slug": "bmp15",
        "symbol": "BMP15",
        "name": "bone morphogenetic protein 15",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/bmp15"
      },
      {
        "slug": "bnc1",
        "symbol": "BNC1",
        "name": "basonuclin zinc finger protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/bnc1"
      },
      {
        "slug": "clpp",
        "symbol": "CLPP",
        "name": "caseinolytic mitochondrial matrix peptidase proteolytic subunit",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/clpp"
      },
      {
        "slug": "cyp19a1",
        "symbol": "CYP19A1",
        "name": "cytochrome P450 family 19 subfamily A member 1",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/cyp19a1"
      },
      {
        "slug": "fancm",
        "symbol": "FANCM",
        "name": "FA complementation group M",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/fancm"
      },
      {
        "slug": "figla",
        "symbol": "FIGLA",
        "name": "folliculogenesis specific bHLH transcription factor",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/figla"
      },
      {
        "slug": "fmr1",
        "symbol": "FMR1",
        "name": "fragile X messenger ribonucleoprotein 1",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/fmr1"
      },
      {
        "slug": "foxl2",
        "symbol": "FOXL2",
        "name": "forkhead box L2",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/foxl2"
      },
      {
        "slug": "fshr",
        "symbol": "FSHR",
        "name": "follicle stimulating hormone receptor",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/fshr"
      },
      {
        "slug": "galt",
        "symbol": "GALT",
        "name": "galactose-1-phosphate uridylyltransferase",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/galt"
      }
    ],
    "sources": {
      "bundleId": "2026.10.18-e609d43e",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}