{
  "url": "https://dantelabs.com/es/genes/dcn",
  "gene": {
    "slug": "dcn",
    "symbol": "DCN",
    "name": "decorin",
    "hgnc": "HGNC:2705",
    "summary": null,
    "location": "12q21.33",
    "locusType": "gene with protein product",
    "aliases": [
      "DSPG2",
      "SLRR1B"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000011465",
    "entrezId": 1634,
    "omim": [
      "125255"
    ],
    "uniprot": [
      "P07585"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "12",
      "start": 91140484,
      "end": 91182817,
      "strand": "-",
      "ensemblTranscript": "ENST00000052754.10",
      "refseqTranscript": "NM_001920.5",
      "ensemblProtein": "ENSP00000052754.5",
      "refseqProtein": "NP_001911.1",
      "exons": [
        {
          "start": 91140484,
          "end": 91146252
        },
        {
          "start": 91151654,
          "end": 91151792
        },
        {
          "start": 91153096,
          "end": 91153189
        },
        {
          "start": 91157075,
          "end": 91157188
        },
        {
          "start": 91158296,
          "end": 91158509
        },
        {
          "start": 91164605,
          "end": 91164717
        },
        {
          "start": 91178342,
          "end": 91178585
        },
        {
          "start": 91182655,
          "end": 91182817
        }
      ],
      "cds": {
        "start": 91146058,
        "end": 91178552
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "12",
      "start": 91539025,
      "end": 91576900,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 90661651,
      "end": 91661650,
      "genes": [
        {
          "symbol": "CCER1",
          "ensemblId": "ENSG00000197651",
          "biotype": "protein_coding",
          "start": 90905622,
          "end": 90955176,
          "strand": "-",
          "slug": "ccer1"
        },
        {
          "symbol": "EPYC",
          "ensemblId": "ENSG00000083782",
          "biotype": "protein_coding",
          "start": 90963682,
          "end": 91005026,
          "strand": "-",
          "slug": "epyc"
        },
        {
          "symbol": "KERA",
          "ensemblId": "ENSG00000139330",
          "biotype": "protein_coding",
          "start": 91050491,
          "end": 91058024,
          "strand": "-",
          "slug": "kera"
        },
        {
          "symbol": "LUM",
          "ensemblId": "ENSG00000139329",
          "biotype": "protein_coding",
          "start": 91102526,
          "end": 91111682,
          "strand": "-",
          "slug": "lum"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-corneal-dystrophies",
        "name": "Distrofias corneales hereditarias",
        "diseases": [
          {
            "mondoId": "MONDO:0018102",
            "name": "Distrofia corneal",
            "genes": 19,
            "inheritance": null,
            "description": "Grupo de afecciones hereditarias que afectan a una o varias capas de la córnea, entre ellas la distrofia endotelial de Fuchs (con frecuencia asociada a una expansión de repeticiones en TCF4), las distrofias granular y reticular relacionadas con TGFBI, y tipos más raros causados por genes como SLC4A11, COL8A2, ZEB1 y CHST6.",
            "management": "Por lo general, se recomienda a los portadores de variantes en TGFBI que eviten la cirugía refractiva láser (LASIK o PRK), ya que puede empeorar los depósitos; el trasplante de córnea puede restaurar la visión en la enfermedad avanzada.",
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/es/conditions/hereditary-corneal-dystrophies"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "band-shaped-corneal-dystrophy",
        "name": "Band-shaped corneal dystrophy",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/band-shaped-corneal-dystrophy"
      },
      {
        "slug": "corneal-dystrophy",
        "name": "Corneal dystrophy",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/corneal-dystrophy"
      },
      {
        "slug": "strabismus",
        "name": "Cross-eyed",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/strabismus"
      },
      {
        "slug": "glaucoma",
        "name": "Glaucoma",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/glaucoma"
      },
      {
        "slug": "increased-corneal-thickness",
        "name": "Increased corneal thickness",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/increased-corneal-thickness"
      },
      {
        "slug": "progressive-visual-loss",
        "name": "Progressive loss of vision",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/progressive-visual-loss"
      }
    ],
    "related": [
      {
        "slug": "chst6",
        "symbol": "CHST6",
        "name": "carbohydrate sulfotransferase 6",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/chst6"
      },
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "name": "collagen type XVII alpha 1 chain",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/col17a1"
      },
      {
        "slug": "col8a2",
        "symbol": "COL8A2",
        "name": "collagen type VIII alpha 2 chain",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/col8a2"
      },
      {
        "slug": "grhl2",
        "symbol": "GRHL2",
        "name": "grainyhead like transcription factor 2",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/grhl2"
      },
      {
        "slug": "gsn",
        "symbol": "GSN",
        "name": "gelsolin",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/gsn"
      },
      {
        "slug": "krt12",
        "symbol": "KRT12",
        "name": "keratin 12",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/krt12"
      },
      {
        "slug": "krt3",
        "symbol": "KRT3",
        "name": "keratin 3",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/krt3"
      },
      {
        "slug": "mcoln1",
        "symbol": "MCOLN1",
        "name": "mucolipin TRP cation channel 1",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/mcoln1"
      },
      {
        "slug": "nlrp1",
        "symbol": "NLRP1",
        "name": "NLR family pyrin domain containing 1",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/nlrp1"
      },
      {
        "slug": "ovol2",
        "symbol": "OVOL2",
        "name": "ovo like zinc finger 2",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/ovol2"
      },
      {
        "slug": "pikfyve",
        "symbol": "PIKFYVE",
        "name": "phosphoinositide kinase, FYVE-type zinc finger containing",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/pikfyve"
      },
      {
        "slug": "prdx3",
        "symbol": "PRDX3",
        "name": "peroxiredoxin 3",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/prdx3"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}