{
  "url": "https://dantelabs.com/es/genes/cryba1",
  "gene": {
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    "name": "crystallin beta A1",
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      "refseqTranscript": "NM_005208.5",
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          "symbol": "TRAF4",
          "ensemblId": "ENSG00000076604",
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        {
          "symbol": "FAM222B",
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        {
          "symbol": "ERAL1",
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        {
          "symbol": "FLOT2",
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        {
          "symbol": "DHRS13",
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        {
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        {
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          "symbol": "SEZ6",
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        {
          "symbol": "MYO18A",
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        {
          "symbol": "NUFIP2",
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        {
          "symbol": "TAOK1",
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        {
          "symbol": "ABHD15",
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        {
          "symbol": "TP53I13",
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        {
          "symbol": "GIT1",
          "ensemblId": "ENSG00000108262",
          "biotype": "protein_coding",
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          "end": 29594054,
          "strand": "-",
          "slug": "git1"
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        {
          "symbol": "ANKRD13B",
          "ensemblId": "ENSG00000198720",
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          "strand": "+",
          "slug": "ankrd13b"
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        {
          "symbol": "CORO6",
          "ensemblId": "ENSG00000167549",
          "biotype": "protein_coding",
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          "strand": "-",
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        },
        {
          "symbol": "SSH2",
          "ensemblId": "ENSG00000141298",
          "biotype": "protein_coding",
          "start": 29625938,
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          "strand": "-",
          "slug": "ssh2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-congenital-and-juvenile-cataract",
        "name": "Catarata congénita y juvenil hereditaria",
        "diseases": [
          {
            "mondoId": "MONDO:0011060",
            "name": "Catarata no sindrómica de inicio temprano",
            "genes": 22,
            "inheritance": null,
            "description": "Catarata que aparece al nacer o en las primeras etapas de la vida sin otras manifestaciones, causada por cambios en genes del cristalino como las cristalinas (CRYAA, CRYBB2, CRYGD y otros), GJA3, GJA8 y MIP.",
            "management": "La detección precoz y la cirugía en los niños ayudan a prevenir la pérdida permanente de visión por ambliopía, y a los familiares se les puede ofrecer revisiones oculares.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "G2P",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/es/conditions/hereditary-congenital-and-juvenile-cataract"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "developmental-cataract",
        "name": "Clouding of the lens of the eye at birth",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/developmental-cataract"
      },
      {
        "slug": "posterior-y-sutural-cataract",
        "name": "Posterior Y-sutural cataract",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/posterior-y-sutural-cataract"
      },
      {
        "slug": "nuclear-cataract",
        "name": "Yellowish cloudy center of lens",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/nuclear-cataract"
      },
      {
        "slug": "zonular-cataract",
        "name": "Zonular cataract",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/zonular-cataract"
      }
    ],
    "related": [
      {
        "slug": "bfsp1",
        "symbol": "BFSP1",
        "name": "beaded filament structural protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/bfsp1"
      },
      {
        "slug": "chmp4b",
        "symbol": "CHMP4B",
        "name": "charged multivesicular body protein 4B",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/chmp4b"
      },
      {
        "slug": "cryab",
        "symbol": "CRYAB",
        "name": "crystallin alpha B",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/cryab"
      },
      {
        "slug": "cryba2",
        "symbol": "CRYBA2",
        "name": "crystallin beta A2",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/cryba2"
      },
      {
        "slug": "cryba4",
        "symbol": "CRYBA4",
        "name": "crystallin beta A4",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/cryba4"
      },
      {
        "slug": "crybb1",
        "symbol": "CRYBB1",
        "name": "crystallin beta B1",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/crybb1"
      },
      {
        "slug": "crybb3",
        "symbol": "CRYBB3",
        "name": "crystallin beta B3",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/crybb3"
      },
      {
        "slug": "crygs",
        "symbol": "CRYGS",
        "name": "crystallin gamma S",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/crygs"
      },
      {
        "slug": "epha2",
        "symbol": "EPHA2",
        "name": "EPH receptor A2",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/epha2"
      },
      {
        "slug": "gcnt2",
        "symbol": "GCNT2",
        "name": "glucosaminyl (N-acetyl) transferase 2 (I blood group)",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/gcnt2"
      },
      {
        "slug": "gja3",
        "symbol": "GJA3",
        "name": "gap junction protein alpha 3",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/gja3"
      },
      {
        "slug": "hsf4",
        "symbol": "HSF4",
        "name": "heat shock transcription factor 4",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/hsf4"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}