{
  "url": "https://dantelabs.com/es/genes/cdkn1b",
  "gene": {
    "slug": "cdkn1b",
    "symbol": "CDKN1B",
    "name": "cyclin dependent kinase inhibitor 1B",
    "hgnc": "HGNC:1785",
    "summary": null,
    "location": "12p13.1",
    "locusType": "gene with protein product",
    "aliases": [
      "KIP1",
      "P27KIP1"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000111276",
    "entrezId": 1027,
    "omim": [
      "600778"
    ],
    "uniprot": [
      "P46527"
    ],
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      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "12",
      "start": 12717368,
      "end": 12722369,
      "strand": "+",
      "ensemblTranscript": "ENST00000228872.9",
      "refseqTranscript": "NM_004064.5",
      "ensemblProtein": "ENSP00000228872.4",
      "refseqProtein": "NP_004055.1",
      "exons": [
        {
          "start": 12717368,
          "end": 12718314
        },
        {
          "start": 12718825,
          "end": 12718954
        },
        {
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        }
      ],
      "cds": {
        "start": 12717840,
        "end": 12718946
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "12",
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      "end": 12875305,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 12219869,
      "end": 13219868,
      "genes": [
        {
          "symbol": "LRP6",
          "ensemblId": "ENSG00000070018",
          "biotype": "protein_coding",
          "start": 12116025,
          "end": 12267193,
          "strand": "-",
          "slug": "lrp6"
        },
        {
          "symbol": "MANSC1",
          "ensemblId": "ENSG00000111261",
          "biotype": "protein_coding",
          "start": 12320182,
          "end": 12350483,
          "strand": "-",
          "slug": "mansc1"
        },
        {
          "symbol": "BORCS5",
          "ensemblId": "ENSG00000165714",
          "biotype": "protein_coding",
          "start": 12357057,
          "end": 12482332,
          "strand": "+",
          "slug": "borcs5"
        },
        {
          "symbol": "DUSP16",
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          "biotype": "protein_coding",
          "start": 12473282,
          "end": 12563147,
          "strand": "-",
          "slug": "dusp16"
        },
        {
          "symbol": "CREBL2",
          "ensemblId": "ENSG00000111269",
          "biotype": "protein_coding",
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          "end": 12645375,
          "strand": "+",
          "slug": "crebl2"
        },
        {
          "symbol": "GPR19",
          "ensemblId": "ENSG00000183150",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "gpr19"
        },
        {
          "symbol": "APOLD1",
          "ensemblId": "ENSG00000178878",
          "biotype": "protein_coding",
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          "strand": "+",
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        {
          "symbol": "DDX47",
          "ensemblId": "ENSG00000213782",
          "biotype": "protein_coding",
          "start": 12813316,
          "end": 12829982,
          "strand": "+",
          "slug": "ddx47"
        },
        {
          "symbol": "GPRC5A",
          "ensemblId": "ENSG00000013588",
          "biotype": "protein_coding",
          "start": 12890782,
          "end": 12917937,
          "strand": "+",
          "slug": "gprc5a"
        },
        {
          "symbol": "GPRC5D",
          "ensemblId": "ENSG00000111291",
          "biotype": "protein_coding",
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          "end": 12952216,
          "strand": "-",
          "slug": "gprc5d"
        },
        {
          "symbol": "HEBP1",
          "ensemblId": "ENSG00000013583",
          "biotype": "protein_coding",
          "start": 12974867,
          "end": 13000310,
          "strand": "-",
          "slug": "hebp1"
        },
        {
          "symbol": "FAM234B",
          "ensemblId": "ENSG00000084444",
          "biotype": "protein_coding",
          "start": 13044185,
          "end": 13142521,
          "strand": "+",
          "slug": "fam234b"
        },
        {
          "symbol": "GSG1",
          "ensemblId": "ENSG00000111305",
          "biotype": "protein_coding",
          "start": 13083532,
          "end": 13103683,
          "strand": "-",
          "slug": "gsg1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000289766",
          "biotype": "protein_coding",
          "start": 13088784,
          "end": 13103484,
          "strand": "-"
        },
        {
          "symbol": "EMP1",
          "ensemblId": "ENSG00000134531",
          "biotype": "protein_coding",
          "start": 13196529,
          "end": 13219941,
          "strand": "+",
          "slug": "emp1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "malignant-endocrine-neoplasm",
        "name": "Neoplasia endocrina maligna",
        "diseases": [
          {
            "mondoId": "MONDO:0017169",
            "name": "Neoplasia endocrina múltiple",
            "genes": 3,
            "inheritance": "autosomal-dominant",
            "description": "La neoplasia endocrina múltiple (NEM) es un grupo de síndromes tumorales hereditarios poco frecuentes caracterizados por la aparición de dos o más tumores en las glándulas endocrinas, en ocasiones con desarrollo tumoral también en otros tejidos u órganos.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ],
              "actionability": 10
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/es/conditions/malignant-endocrine-neoplasm"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "amenorrhea",
        "name": "Abnormal absence of menstruation",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/amenorrhea"
      },
      {
        "slug": "abnormal-circulating-aldosterone-concentration",
        "name": "Abnormal circulating aldosterone",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-circulating-aldosterone-concentration"
      },
      {
        "slug": "abnormality-of-pancreas-physiology",
        "name": "Abnormality of pancreas physiology",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-pancreas-physiology"
      },
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "systems": [],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      },
      {
        "slug": "gastroesophageal-reflux",
        "name": "Acid reflux",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/gastroesophageal-reflux"
      },
      {
        "slug": "adrenocortical-abnormality",
        "name": "Adrenocortical abnormality",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/adrenocortical-abnormality"
      },
      {
        "slug": "adrenocortical-adenoma",
        "name": "Adrenocortical adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/adrenocortical-adenoma"
      },
      {
        "slug": "adrenocortical-carcinoma",
        "name": "Adrenocortical carcinoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/adrenocortical-carcinoma"
      },
      {
        "slug": "angiofibromas",
        "name": "Angiofibromas",
        "systems": [
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/angiofibromas"
      },
      {
        "slug": "anorexia",
        "name": "Anorexia",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anorexia"
      },
      {
        "slug": "atypical-absence-status-epilepticus",
        "name": "Atypical absence status epilepticus",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/atypical-absence-status-epilepticus"
      },
      {
        "slug": "melena",
        "name": "Black feces",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/melena"
      },
      {
        "slug": "osteolysis",
        "name": "Breakdown of bone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/osteolysis"
      },
      {
        "slug": "neoplasm-of-the-pancreas",
        "name": "Cancer of the pancreas",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-pancreas"
      },
      {
        "slug": "carcinoid-tumor",
        "name": "Carcinoid tumor",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/carcinoid-tumor"
      },
      {
        "slug": "carcinoma",
        "name": "Carcinoma",
        "systems": [
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/carcinoma"
      },
      {
        "slug": "cervix-cancer",
        "name": "Cervix cancer",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cervix-cancer"
      },
      {
        "slug": "coma",
        "name": "Coma",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/coma"
      },
      {
        "slug": "confetti-like-hypopigmented-macules",
        "name": "Confetti-like hypopigmented macules",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/confetti-like-hypopigmented-macules"
      },
      {
        "slug": "confusion",
        "name": "Confusion",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/confusion"
      },
      {
        "slug": "constipation",
        "name": "Constipation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/constipation"
      },
      {
        "slug": "cranial-nerve-compression",
        "name": "Cranial nerve compression",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cranial-nerve-compression"
      },
      {
        "slug": "decreased-male-libido",
        "name": "Decreased male libido",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-male-libido"
      },
      {
        "slug": "decreased-vigilance",
        "name": "Decreased vigilance",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-vigilance"
      },
      {
        "slug": "dehydration",
        "name": "Dehydration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dehydration"
      },
      {
        "slug": "depression",
        "name": "Depression",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/depression"
      },
      {
        "slug": "diarrhea",
        "name": "Diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/diarrhea"
      },
      {
        "slug": "impotence",
        "name": "Difficulty getting a full erection",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/impotence"
      },
      {
        "slug": "duodenal-ulcer",
        "name": "Duodenal ulcer",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/duodenal-ulcer"
      },
      {
        "slug": "hyperparathyroidism",
        "name": "Elevated blood parathyroid hormone level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hyperparathyroidism"
      },
      {
        "slug": "elevated-circulating-calcitonin-concentration",
        "name": "Elevated calcitonin",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/elevated-circulating-calcitonin-concentration"
      },
      {
        "slug": "elevated-circulating-parathyroid-hormone-level",
        "name": "Elevated circulating parathyroid hormone level",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-parathyroid-hormone-level"
      },
      {
        "slug": "hypergastrinemia",
        "name": "Elevated gastrin in the blood",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypergastrinemia"
      },
      {
        "slug": "hypercalciuria",
        "name": "Elevated urine calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypercalciuria"
      },
      {
        "slug": "parathyroid-hyperplasia",
        "name": "Enlarged parathyroid glands",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/parathyroid-hyperplasia"
      },
      {
        "slug": "goiter",
        "name": "Enlarged thyroid gland in neck",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/goiter"
      },
      {
        "slug": "ependymoma",
        "name": "Ependymoma",
        "systems": [
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/ependymoma"
      },
      {
        "slug": "extrahepatic-cholestasis",
        "name": "Extrahepatic cholestasis",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/extrahepatic-cholestasis"
      },
      {
        "slug": "gingival-fibromatosis",
        "name": "Gingival fibromatosis",
        "systems": [
          "abnormality-of-head-or-neck",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gingival-fibromatosis"
      },
      {
        "slug": "glucagonoma",
        "name": "Glucagonoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/glucagonoma"
      },
      {
        "slug": "elevated-circulating-growth-hormone-concentration",
        "name": "Growth hormone excess",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-growth-hormone-concentration"
      },
      {
        "slug": "hashimoto-thyroiditis",
        "name": "Hashimoto thyroiditis",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hashimoto-thyroiditis"
      },
      {
        "slug": "headache",
        "name": "Headache",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/headache"
      },
      {
        "slug": "hypercalcemia",
        "name": "High blood calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypercalcemia"
      },
      {
        "slug": "fasting-hyperinsulinemia",
        "name": "High blood insulin levels while fasting",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fasting-hyperinsulinemia"
      },
      {
        "slug": "hypertension",
        "name": "High blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertension"
      },
      {
        "slug": "increased-urinary-cortisol-level",
        "name": "High urine cortisol level",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-urinary-cortisol-level"
      },
      {
        "slug": "hyperinsulinemic-hypoglycemia",
        "name": "Hyperinsulinemic hypoglycemia",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperinsulinemic-hypoglycemia"
      },
      {
        "slug": "impairment-of-activities-of-daily-living",
        "name": "Impairment of activities of daily living",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/impairment-of-activities-of-daily-living"
      },
      {
        "slug": "increased-circulating-cortisol-level",
        "name": "Increased circulating cortisol level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-circulating-cortisol-level"
      },
      {
        "slug": "increased-glucagon-level",
        "name": "Increased glucagon level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-glucagon-level"
      },
      {
        "slug": "increased-serum-serotonin",
        "name": "Increased serum serotonin",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/increased-serum-serotonin"
      },
      {
        "slug": "increased-susceptibility-to-fractures",
        "name": "Increased susceptibility to fractures",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-susceptibility-to-fractures"
      },
      {
        "slug": "esophagitis",
        "name": "Inflammation of the esophagus",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/esophagitis"
      },
      {
        "slug": "insulinoma",
        "name": "Insulinoma",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/insulinoma"
      },
      {
        "slug": "episodic-abdominal-pain",
        "name": "Intermittent abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/episodic-abdominal-pain"
      },
      {
        "slug": "intestinal-carcinoid",
        "name": "Intestinal carcinoid",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intestinal-carcinoid"
      },
      {
        "slug": "kidney-stone",
        "name": "Kidney stone",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/kidney-stone"
      },
      {
        "slug": "large-cafe-au-lait-macules-with-irregular-margins",
        "name": "Large cafe-au-lait macules with irregular margins",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/large-cafe-au-lait-macules-with-irregular-margins"
      },
      {
        "slug": "lethargy",
        "name": "Lethargy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lethargy"
      },
      {
        "slug": "reduced-bone-mineral-density",
        "name": "Low solidness and mass of the bones",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/reduced-bone-mineral-density"
      },
      {
        "slug": "multiple-lipomas",
        "name": "Multiple fatty lumps",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/multiple-lipomas"
      },
      {
        "slug": "nausea",
        "name": "Nausea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nausea"
      },
      {
        "slug": "neuroendocrine-neoplasm",
        "name": "Neuroendocrine neoplasm",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neuroendocrine-neoplasm"
      },
      {
        "slug": "meningioma",
        "name": "Noncancerous growth of membranes covering brain",
        "systems": [
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/meningioma"
      },
      {
        "slug": "pituitary-adenoma",
        "name": "Noncancerous tumor in pituitary gland",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pituitary-adenoma"
      },
      {
        "slug": "pancreatic-endocrine-tumor",
        "name": "Pancreatic endocrine tumor",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pancreatic-endocrine-tumor"
      },
      {
        "slug": "parathyroid-adenoma",
        "name": "Parathyroid adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/parathyroid-adenoma"
      },
      {
        "slug": "parathyroid-carcinoma",
        "name": "Parathyroid carcinoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/parathyroid-carcinoma"
      },
      {
        "slug": "pheochromocytoma",
        "name": "Pheochromocytoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/pheochromocytoma"
      },
      {
        "slug": "pituitary-corticotropic-cell-adenoma",
        "name": "Pituitary corticotropic cell adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pituitary-corticotropic-cell-adenoma"
      },
      {
        "slug": "pituitary-gonadotropic-cell-adenoma",
        "name": "Pituitary gonadotropic cell adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/pituitary-gonadotropic-cell-adenoma"
      },
      {
        "slug": "pituitary-growth-hormone-cell-adenoma",
        "name": "Pituitary growth hormone cell adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pituitary-growth-hormone-cell-adenoma"
      },
      {
        "slug": "pituitary-null-cell-adenoma",
        "name": "Pituitary null cell adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pituitary-null-cell-adenoma"
      },
      {
        "slug": "pituitary-prolactin-cell-adenoma",
        "name": "Pituitary prolactin cell adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pituitary-prolactin-cell-adenoma"
      },
      {
        "slug": "pituitary-thyrotropic-cell-adenoma",
        "name": "Pituitary thyrotropic cell adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/pituitary-thyrotropic-cell-adenoma"
      },
      {
        "slug": "primary-hypercortisolism",
        "name": "Primary hypercortisolism",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/primary-hypercortisolism"
      },
      {
        "slug": "primary-hyperparathyroidism",
        "name": "Primary hyperparathyroidism",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/primary-hyperparathyroidism"
      },
      {
        "slug": "proportionate-tall-stature",
        "name": "Proportionate tall stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/proportionate-tall-stature"
      },
      {
        "slug": "pulmonary-carcinoid-tumor",
        "name": "Pulmonary carcinoid tumor",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pulmonary-carcinoid-tumor"
      },
      {
        "slug": "erythema",
        "name": "Redness of skin or mucous membrane",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/erythema"
      },
      {
        "slug": "renal-angiomyolipoma",
        "name": "Renal angiomyolipoma",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/renal-angiomyolipoma"
      },
      {
        "slug": "short-attention-span",
        "name": "Short attention span",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-attention-span"
      },
      {
        "slug": "shortened-qt-interval",
        "name": "Shortened QT interval",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/shortened-qt-interval"
      },
      {
        "slug": "peptic-ulcer",
        "name": "Sore in the lining of gastrointestinal tract",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/peptic-ulcer"
      },
      {
        "slug": "galactorrhea",
        "name": "Spontaneous milk flow from breast",
        "systems": [
          "abnormality-of-the-breast"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/galactorrhea"
      },
      {
        "slug": "subcutaneous-lipoma",
        "name": "Subcutaneous lipoma",
        "systems": [
          "abnormality-of-the-integument",
          "abnormality-of-the-musculoskeletal-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/subcutaneous-lipoma"
      },
      {
        "slug": "testicular-neoplasm",
        "name": "Testicular cancer",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/testicular-neoplasm"
      },
      {
        "slug": "thymoma",
        "name": "Thymoma",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-immune-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/thymoma"
      },
      {
        "slug": "thyroid-adenoma",
        "name": "Thyroid adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thyroid-adenoma"
      },
      {
        "slug": "thyroid-carcinoma",
        "name": "Thyroid carcinoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thyroid-carcinoma"
      },
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      },
      {
        "slug": "vomiting",
        "name": "Vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/vomiting"
      },
      {
        "slug": "hematemesis",
        "name": "Vomiting blood",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hematemesis"
      },
      {
        "slug": "weight-loss",
        "name": "Weight loss",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/weight-loss"
      },
      {
        "slug": "zollinger-ellison-syndrome",
        "name": "Zollinger-Ellison syndrome",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/zollinger-ellison-syndrome"
      }
    ],
    "related": [
      {
        "slug": "men1",
        "symbol": "MEN1",
        "name": "menin 1",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/men1"
      },
      {
        "slug": "ret",
        "symbol": "RET",
        "name": "ret proto-oncogene",
        "shared": 1,
        "url": "https://dantelabs.com/es/genes/ret"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}