{
  "url": "https://dantelabs.com/traits/synotia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "synotia",
    "id": "HP:0100663",
    "name": "Synotia",
    "definition": "A congenital malformation characterized by the union or approximation of the ears in front of the neck, often accompanied by the absence or defective development of the lower jaw.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-ear",
        "name": "Abnormality of the ear",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ear"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-location-of-ears",
        "name": "Abnormal location of ears",
        "url": "https://dantelabs.com/traits/abnormal-location-of-ears"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "prrx1",
        "symbol": "PRRX1",
        "hgnc": "HGNC:9142",
        "name": "paired related homeobox 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prrx1"
      },
      {
        "slug": "otx2",
        "symbol": "OTX2",
        "hgnc": "HGNC:8522",
        "name": "orthodenticle homeobox 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otx2"
      }
    ]
  }
}