{
  "url": "https://dantelabs.com/traits/refractory-anemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "refractory-anemia",
    "id": "HP:0005505",
    "name": "Refractory anemia",
    "synonyms": [
      "Refractory anaemia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "url": "https://dantelabs.com/traits/anemia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cp",
        "symbol": "CP",
        "hgnc": "HGNC:2295",
        "name": "ceruloplasmin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cp"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "grem1",
        "symbol": "GREM1",
        "hgnc": "HGNC:2001",
        "name": "gremlin 1, DAN family BMP antagonist",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grem1"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "ddx41",
        "symbol": "DDX41",
        "hgnc": "HGNC:18674",
        "name": "DEAD-box helicase 41",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddx41"
      },
      {
        "slug": "tbxas1",
        "symbol": "TBXAS1",
        "hgnc": "HGNC:11609",
        "name": "thromboxane A synthase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbxas1"
      }
    ]
  }
}