{
  "url": "https://dantelabs.com/traits/oligodactyly",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "oligodactyly",
    "id": "HP:0012165",
    "name": "Oligodactyly",
    "definition": "A developmental defect resulting in the presence of fewer than the normal number of digits.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-digit-morphology",
        "name": "Abnormality of fingers or toes",
        "url": "https://dantelabs.com/traits/abnormal-digit-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "foot-oligodactyly",
        "name": "Missing toes",
        "genes": 11,
        "url": "https://dantelabs.com/traits/foot-oligodactyly"
      }
    ],
    "genes": [
      {
        "slug": "faap100",
        "symbol": "FAAP100",
        "hgnc": "HGNC:26171",
        "name": "FA core complex associated protein 100",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faap100"
      },
      {
        "slug": "ripk4",
        "symbol": "RIPK4",
        "hgnc": "HGNC:496",
        "name": "receptor interacting serine/threonine kinase 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ripk4"
      },
      {
        "slug": "apc",
        "symbol": "APC",
        "hgnc": "HGNC:583",
        "name": "APC regulator of Wnt signaling pathway",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc"
      },
      {
        "slug": "btrc",
        "symbol": "BTRC",
        "hgnc": "HGNC:1144",
        "name": "beta-transducin repeat containing E3 ubiquitin protein ligase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btrc"
      },
      {
        "slug": "dlx5",
        "symbol": "DLX5",
        "hgnc": "HGNC:2918",
        "name": "distal-less homeobox 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlx5"
      },
      {
        "slug": "dlx6",
        "symbol": "DLX6",
        "hgnc": "HGNC:2919",
        "name": "distal-less homeobox 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlx6"
      },
      {
        "slug": "eps15l1",
        "symbol": "EPS15L1",
        "hgnc": "HGNC:24634",
        "name": "epidermal growth factor receptor pathway substrate 15 like 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eps15l1"
      },
      {
        "slug": "fbxw4",
        "symbol": "FBXW4",
        "hgnc": "HGNC:10847",
        "name": "F-box and WD repeat domain containing 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxw4"
      },
      {
        "slug": "lrp4",
        "symbol": "LRP4",
        "hgnc": "HGNC:6696",
        "name": "LDL receptor related protein 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp4"
      },
      {
        "slug": "sem1",
        "symbol": "SEM1",
        "hgnc": "HGNC:10845",
        "name": "SEM1 26S proteasome subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sem1"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "wnt10b",
        "symbol": "WNT10B",
        "hgnc": "HGNC:12775",
        "name": "Wnt family member 10B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10b"
      },
      {
        "slug": "h4c3",
        "symbol": "H4C3",
        "hgnc": "HGNC:4787",
        "name": "H4 clustered histone 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h4c3"
      },
      {
        "slug": "recql4",
        "symbol": "RECQL4",
        "hgnc": "HGNC:9949",
        "name": "RecQ like helicase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/recql4"
      },
      {
        "slug": "brd4",
        "symbol": "BRD4",
        "hgnc": "HGNC:13575",
        "name": "bromodomain containing 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brd4"
      },
      {
        "slug": "gli3",
        "symbol": "GLI3",
        "hgnc": "HGNC:4319",
        "name": "GLI family zinc finger 3",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gli3"
      },
      {
        "slug": "hdac8",
        "symbol": "HDAC8",
        "hgnc": "HGNC:13315",
        "name": "histone deacetylase 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hdac8"
      },
      {
        "slug": "mau2",
        "symbol": "MAU2",
        "hgnc": "HGNC:29140",
        "name": "MAU2 sister chromatid cohesion factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mau2"
      },
      {
        "slug": "mbtps2",
        "symbol": "MBTPS2",
        "hgnc": "HGNC:15455",
        "name": "membrane bound transcription factor peptidase, site 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbtps2"
      },
      {
        "slug": "nipbl",
        "symbol": "NIPBL",
        "hgnc": "HGNC:28862",
        "name": "NIPBL cohesin loading factor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nipbl"
      },
      {
        "slug": "nsdhl",
        "symbol": "NSDHL",
        "hgnc": "HGNC:13398",
        "name": "NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsdhl"
      },
      {
        "slug": "rad21",
        "symbol": "RAD21",
        "hgnc": "HGNC:9811",
        "name": "RAD21 cohesin complex component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad21"
      },
      {
        "slug": "smc1a",
        "symbol": "SMC1A",
        "hgnc": "HGNC:11111",
        "name": "structural maintenance of chromosomes 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc1a"
      },
      {
        "slug": "smc3",
        "symbol": "SMC3",
        "hgnc": "HGNC:2468",
        "name": "structural maintenance of chromosomes 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc3"
      },
      {
        "slug": "cyp26b1",
        "symbol": "CYP26B1",
        "hgnc": "HGNC:20581",
        "name": "cytochrome P450 family 26 subfamily B member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp26b1"
      },
      {
        "slug": "donson",
        "symbol": "DONSON",
        "hgnc": "HGNC:2993",
        "name": "DNA replication fork stabilization factor DONSON",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/donson"
      },
      {
        "slug": "hoxd13",
        "symbol": "HOXD13",
        "hgnc": "HGNC:5136",
        "name": "homeobox D13",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxd13"
      },
      {
        "slug": "wnt7a",
        "symbol": "WNT7A",
        "hgnc": "HGNC:12786",
        "name": "Wnt family member 7A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt7a"
      }
    ]
  }
}