{
  "url": "https://dantelabs.com/traits/multiple-myeloma",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "multiple-myeloma",
    "id": "HP:0006775",
    "name": "Multiple myeloma",
    "definition": "A malignant plasma cell tumor growing within soft tissue or within the skeleton.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "hematological-neoplasm",
        "name": "Blood tumor",
        "url": "https://dantelabs.com/traits/hematological-neoplasm"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "scarb2",
        "symbol": "SCARB2",
        "hgnc": "HGNC:1665",
        "name": "scavenger receptor class B member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarb2"
      },
      {
        "slug": "asxl1",
        "symbol": "ASXL1",
        "hgnc": "HGNC:18318",
        "name": "ASXL transcriptional regulator 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asxl1"
      },
      {
        "slug": "kit",
        "symbol": "KIT",
        "hgnc": "HGNC:6342",
        "name": "KIT proto-oncogene, receptor tyrosine kinase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kit"
      },
      {
        "slug": "srsf2",
        "symbol": "SRSF2",
        "hgnc": "HGNC:10783",
        "name": "serine and arginine rich splicing factor 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srsf2"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "ccnd1",
        "symbol": "CCND1",
        "hgnc": "HGNC:1582",
        "name": "cyclin D1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnd1"
      },
      {
        "slug": "lig4",
        "symbol": "LIG4",
        "hgnc": "HGNC:6601",
        "name": "DNA ligase 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lig4"
      }
    ]
  }
}