{
  "url": "https://dantelabs.com/traits/lymphadenitis",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "lymphadenitis",
    "id": "HP:0002840",
    "name": "Inflammation of the lymph nodes",
    "label": "Lymphadenitis",
    "definition": "Inflammation of a lymph node.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-lymph-node-morphology",
        "name": "Abnormal lymph node histology",
        "url": "https://dantelabs.com/traits/abnormal-lymph-node-morphology"
      },
      {
        "slug": "increased-inflammatory-response",
        "name": "Increased inflammatory response",
        "url": "https://dantelabs.com/traits/increased-inflammatory-response"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "irf1",
        "symbol": "IRF1",
        "hgnc": "HGNC:6116",
        "name": "interferon regulatory factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf1"
      },
      {
        "slug": "ptcra",
        "symbol": "PTCRA",
        "hgnc": "HGNC:21290",
        "name": "pre T cell antigen receptor alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptcra"
      },
      {
        "slug": "stat2",
        "symbol": "STAT2",
        "hgnc": "HGNC:11363",
        "name": "signal transducer and activator of transcription 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat2"
      },
      {
        "slug": "mvk",
        "symbol": "MVK",
        "hgnc": "HGNC:7530",
        "name": "mevalonate kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mvk"
      },
      {
        "slug": "il12rb1",
        "symbol": "IL12RB1",
        "hgnc": "HGNC:5971",
        "name": "interleukin 12 receptor subunit beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12rb1"
      },
      {
        "slug": "irf8",
        "symbol": "IRF8",
        "hgnc": "HGNC:5358",
        "name": "interferon regulatory factor 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf8"
      },
      {
        "slug": "rac2",
        "symbol": "RAC2",
        "hgnc": "HGNC:9802",
        "name": "Rac family small GTPase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rac2"
      },
      {
        "slug": "rbck1",
        "symbol": "RBCK1",
        "hgnc": "HGNC:15864",
        "name": "RANBP2-type and C3HC4-type zinc finger containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbck1"
      },
      {
        "slug": "rfx5",
        "symbol": "RFX5",
        "hgnc": "HGNC:9986",
        "name": "regulatory factor X5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx5"
      },
      {
        "slug": "traf3",
        "symbol": "TRAF3",
        "hgnc": "HGNC:12033",
        "name": "TNF receptor associated factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3"
      },
      {
        "slug": "cybc1",
        "symbol": "CYBC1",
        "hgnc": "HGNC:28672",
        "name": "cytochrome b-245 chaperone 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybc1"
      },
      {
        "slug": "rag1",
        "symbol": "RAG1",
        "hgnc": "HGNC:9831",
        "name": "recombination activating 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag1"
      },
      {
        "slug": "rag2",
        "symbol": "RAG2",
        "hgnc": "HGNC:9832",
        "name": "recombination activating 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag2"
      },
      {
        "slug": "zap70",
        "symbol": "ZAP70",
        "hgnc": "HGNC:12858",
        "name": "zeta chain of T cell receptor associated protein kinase 70",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zap70"
      },
      {
        "slug": "cxcr4",
        "symbol": "CXCR4",
        "hgnc": "HGNC:2561",
        "name": "C-X-C motif chemokine receptor 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cxcr4"
      },
      {
        "slug": "cyba",
        "symbol": "CYBA",
        "hgnc": "HGNC:2577",
        "name": "cytochrome b-245 alpha chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyba"
      },
      {
        "slug": "cybb",
        "symbol": "CYBB",
        "hgnc": "HGNC:2578",
        "name": "cytochrome b-245 beta chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybb"
      },
      {
        "slug": "myd88",
        "symbol": "MYD88",
        "hgnc": "HGNC:7562",
        "name": "MYD88 innate immune signal transduction adaptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myd88"
      },
      {
        "slug": "ncf1",
        "symbol": "NCF1",
        "hgnc": "HGNC:7660",
        "name": "neutrophil cytosolic factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncf1"
      },
      {
        "slug": "ncf2",
        "symbol": "NCF2",
        "hgnc": "HGNC:7661",
        "name": "neutrophil cytosolic factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncf2"
      }
    ]
  }
}