{
  "url": "https://dantelabs.com/traits/iridodonesis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "iridodonesis",
    "id": "HP:0100693",
    "name": "Iridodonesis",
    "definition": "Tremulousness of the iris on movement of the eye, occurring in subluxation of the lens.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-iris-morphology",
        "name": "Abnormality of the iris",
        "url": "https://dantelabs.com/traits/abnormality-iris-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "fbn1",
        "symbol": "FBN1",
        "hgnc": "HGNC:3603",
        "name": "fibrillin 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fbn1"
      },
      {
        "slug": "cpamd8",
        "symbol": "CPAMD8",
        "hgnc": "HGNC:23228",
        "name": "C3 and PZP like alpha-2-macroglobulin domain containing 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpamd8"
      },
      {
        "slug": "cyp1b1",
        "symbol": "CYP1B1",
        "hgnc": "HGNC:2597",
        "name": "cytochrome P450 family 1 subfamily B member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp1b1"
      },
      {
        "slug": "ltbp2",
        "symbol": "LTBP2",
        "hgnc": "HGNC:6715",
        "name": "latent transforming growth factor beta binding protein 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ltbp2"
      },
      {
        "slug": "myoc",
        "symbol": "MYOC",
        "hgnc": "HGNC:7610",
        "name": "myocilin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myoc"
      },
      {
        "slug": "tek",
        "symbol": "TEK",
        "hgnc": "HGNC:11724",
        "name": "TEK receptor tyrosine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tek"
      },
      {
        "slug": "adamts17",
        "symbol": "ADAMTS17",
        "hgnc": "HGNC:17109",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 17",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts17"
      },
      {
        "slug": "chrdl1",
        "symbol": "CHRDL1",
        "hgnc": "HGNC:29861",
        "name": "chordin like 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrdl1"
      }
    ]
  }
}