{
  "url": "https://dantelabs.com/traits/hypothermia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypothermia",
    "id": "HP:0002045",
    "name": "Hypothermia",
    "definition": "Reduced body temperature due to failed thermoregulation.",
    "synonyms": [
      "Abnormally low body temperature"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-temperature-regulation",
        "name": "Abnormality of temperature regulation",
        "url": "https://dantelabs.com/traits/abnormality-of-temperature-regulation"
      }
    ],
    "narrower": [
      {
        "slug": "intermittent-hypothermia",
        "name": "Intermittent hypothermia",
        "genes": 3,
        "url": "https://dantelabs.com/traits/intermittent-hypothermia"
      }
    ],
    "genes": [
      {
        "slug": "brat1",
        "symbol": "BRAT1",
        "hgnc": "HGNC:21701",
        "name": "BRCA1 associated ATM activator 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brat1"
      },
      {
        "slug": "coa6",
        "symbol": "COA6",
        "hgnc": "HGNC:18025",
        "name": "cytochrome c oxidase assembly factor 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coa6"
      },
      {
        "slug": "coq9",
        "symbol": "COQ9",
        "hgnc": "HGNC:25302",
        "name": "coenzyme Q9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq9"
      },
      {
        "slug": "gabra2",
        "symbol": "GABRA2",
        "hgnc": "HGNC:4076",
        "name": "gamma-aminobutyric acid type A receptor subunit alpha2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabra2"
      },
      {
        "slug": "kdm6b",
        "symbol": "KDM6B",
        "hgnc": "HGNC:29012",
        "name": "lysine demethylase 6B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6b"
      },
      {
        "slug": "micos13",
        "symbol": "MICOS13",
        "hgnc": "HGNC:33702",
        "name": "mitochondrial contact site and cristae organizing system subunit 13",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/micos13"
      },
      {
        "slug": "slc52a1",
        "symbol": "SLC52A1",
        "hgnc": "HGNC:30225",
        "name": "solute carrier family 52 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc52a1"
      },
      {
        "slug": "suclg1",
        "symbol": "SUCLG1",
        "hgnc": "HGNC:11449",
        "name": "succinate-CoA ligase GDP/ADP-forming subunit alpha",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/suclg1"
      },
      {
        "slug": "uqcrfs1",
        "symbol": "UQCRFS1",
        "hgnc": "HGNC:12587",
        "name": "ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcrfs1"
      },
      {
        "slug": "tspyl1",
        "symbol": "TSPYL1",
        "hgnc": "HGNC:12382",
        "name": "TSPY like 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tspyl1"
      },
      {
        "slug": "atp7a",
        "symbol": "ATP7A",
        "hgnc": "HGNC:869",
        "name": "ATPase copper transporting alpha",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/atp7a"
      },
      {
        "slug": "hesx1",
        "symbol": "HESX1",
        "hgnc": "HGNC:4877",
        "name": "HESX homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hesx1"
      },
      {
        "slug": "lhx3",
        "symbol": "LHX3",
        "hgnc": "HGNC:6595",
        "name": "LIM homeobox 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhx3"
      },
      {
        "slug": "lhx4",
        "symbol": "LHX4",
        "hgnc": "HGNC:21734",
        "name": "LIM homeobox 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhx4"
      },
      {
        "slug": "nags",
        "symbol": "NAGS",
        "hgnc": "HGNC:17996",
        "name": "N-acetylglutamate synthase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nags"
      },
      {
        "slug": "otc",
        "symbol": "OTC",
        "hgnc": "HGNC:8512",
        "name": "ornithine transcarbamylase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otc"
      },
      {
        "slug": "pou1f1",
        "symbol": "POU1F1",
        "hgnc": "HGNC:9210",
        "name": "POU class 1 homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pou1f1"
      },
      {
        "slug": "prop1",
        "symbol": "PROP1",
        "hgnc": "HGNC:9455",
        "name": "PROP paired-like homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prop1"
      },
      {
        "slug": "tshb",
        "symbol": "TSHB",
        "hgnc": "HGNC:12372",
        "name": "thyroid stimulating hormone subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshb"
      },
      {
        "slug": "acadvl",
        "symbol": "ACADVL",
        "hgnc": "HGNC:92",
        "name": "acyl-CoA dehydrogenase very long chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acadvl"
      },
      {
        "slug": "cacna1c",
        "symbol": "CACNA1C",
        "hgnc": "HGNC:1390",
        "name": "calcium voltage-gated channel subunit alpha1 C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1c"
      },
      {
        "slug": "cd28",
        "symbol": "CD28",
        "hgnc": "HGNC:1653",
        "name": "CD28 molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd28"
      },
      {
        "slug": "creld1",
        "symbol": "CRELD1",
        "hgnc": "HGNC:14630",
        "name": "CRELD disulfide isomerase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/creld1"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "dbh",
        "symbol": "DBH",
        "hgnc": "HGNC:2689",
        "name": "dopamine beta-hydroxylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dbh"
      },
      {
        "slug": "duox2",
        "symbol": "DUOX2",
        "hgnc": "HGNC:13273",
        "name": "dual oxidase 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/duox2"
      },
      {
        "slug": "duoxa2",
        "symbol": "DUOXA2",
        "hgnc": "HGNC:32698",
        "name": "dual oxidase maturation factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/duoxa2"
      },
      {
        "slug": "ivd",
        "symbol": "IVD",
        "hgnc": "HGNC:6186",
        "name": "isovaleryl-CoA dehydrogenase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ivd"
      },
      {
        "slug": "iyd",
        "symbol": "IYD",
        "hgnc": "HGNC:21071",
        "name": "iodotyrosine deiodinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iyd"
      },
      {
        "slug": "lmnb1",
        "symbol": "LMNB1",
        "hgnc": "HGNC:6637",
        "name": "lamin B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmnb1"
      },
      {
        "slug": "mmachc",
        "symbol": "MMACHC",
        "hgnc": "HGNC:24525",
        "name": "metabolism of cobalamin associated C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmachc"
      },
      {
        "slug": "mt-atp6",
        "symbol": "MT-ATP6",
        "hgnc": "HGNC:7414",
        "name": "mitochondrially encoded ATP synthase membrane subunit 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-atp6"
      },
      {
        "slug": "mt-nd1",
        "symbol": "MT-ND1",
        "hgnc": "HGNC:7455",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd1"
      },
      {
        "slug": "mt-nd2",
        "symbol": "MT-ND2",
        "hgnc": "HGNC:7456",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd2"
      },
      {
        "slug": "mt-nd3",
        "symbol": "MT-ND3",
        "hgnc": "HGNC:7458",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd3"
      },
      {
        "slug": "mt-nd4",
        "symbol": "MT-ND4",
        "hgnc": "HGNC:7459",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd4"
      },
      {
        "slug": "mt-nd5",
        "symbol": "MT-ND5",
        "hgnc": "HGNC:7461",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd5"
      },
      {
        "slug": "mt-nd6",
        "symbol": "MT-ND6",
        "hgnc": "HGNC:7462",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd6"
      },
      {
        "slug": "mt-tk",
        "symbol": "MT-TK",
        "hgnc": "HGNC:7489",
        "name": "mitochondrially encoded tRNA-Lys (AAA/G)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tk"
      },
      {
        "slug": "mt-tl1",
        "symbol": "MT-TL1",
        "hgnc": "HGNC:7490",
        "name": "mitochondrially encoded tRNA-Leu (UUA/G) 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tl1"
      },
      {
        "slug": "mt-tv",
        "symbol": "MT-TV",
        "hgnc": "HGNC:7500",
        "name": "mitochondrially encoded tRNA-Val (GUN)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tv"
      },
      {
        "slug": "mt-tw",
        "symbol": "MT-TW",
        "hgnc": "HGNC:7501",
        "name": "mitochondrially encoded tRNA-Trp (UGA/G)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tw"
      },
      {
        "slug": "scn10a",
        "symbol": "SCN10A",
        "hgnc": "HGNC:10582",
        "name": "sodium voltage-gated channel alpha subunit 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn10a"
      },
      {
        "slug": "scn11a",
        "symbol": "SCN11A",
        "hgnc": "HGNC:10583",
        "name": "sodium voltage-gated channel alpha subunit 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn11a"
      },
      {
        "slug": "scn9a",
        "symbol": "SCN9A",
        "hgnc": "HGNC:10597",
        "name": "sodium voltage-gated channel alpha subunit 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn9a"
      },
      {
        "slug": "slc25a20",
        "symbol": "SLC25A20",
        "hgnc": "HGNC:1421",
        "name": "solute carrier family 25 member 20",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a20"
      },
      {
        "slug": "slc5a5",
        "symbol": "SLC5A5",
        "hgnc": "HGNC:11040",
        "name": "solute carrier family 5 member 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc5a5"
      },
      {
        "slug": "tbck",
        "symbol": "TBCK",
        "hgnc": "HGNC:28261",
        "name": "TBC1 domain containing kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbck"
      },
      {
        "slug": "tg",
        "symbol": "TG",
        "hgnc": "HGNC:11764",
        "name": "thyroglobulin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tg"
      },
      {
        "slug": "tnfrsf1b",
        "symbol": "TNFRSF1B",
        "hgnc": "HGNC:11917",
        "name": "TNF receptor superfamily member 1B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf1b"
      },
      {
        "slug": "tpo",
        "symbol": "TPO",
        "hgnc": "HGNC:12015",
        "name": "thyroid peroxidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpo"
      },
      {
        "slug": "btnl2",
        "symbol": "BTNL2",
        "hgnc": "HGNC:1142",
        "name": "butyrophilin like 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btnl2"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "hmgcl",
        "symbol": "HMGCL",
        "hgnc": "HGNC:5005",
        "name": "3-hydroxy-3-methylglutaryl-CoA lyase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmgcl"
      },
      {
        "slug": "ntrk1",
        "symbol": "NTRK1",
        "hgnc": "HGNC:8031",
        "name": "neurotrophic receptor tyrosine kinase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ntrk1"
      },
      {
        "slug": "tshr",
        "symbol": "TSHR",
        "hgnc": "HGNC:12373",
        "name": "thyroid stimulating hormone receptor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshr"
      },
      {
        "slug": "acadsb",
        "symbol": "ACADSB",
        "hgnc": "HGNC:91",
        "name": "acyl-CoA dehydrogenase short/branched chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acadsb"
      },
      {
        "slug": "dguok",
        "symbol": "DGUOK",
        "hgnc": "HGNC:2858",
        "name": "deoxyguanosine kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dguok"
      },
      {
        "slug": "pax8",
        "symbol": "PAX8",
        "hgnc": "HGNC:8622",
        "name": "paired box 8",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax8"
      }
    ]
  }
}