{
  "url": "https://dantelabs.com/traits/hypothalamic-hamartoma",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypothalamic-hamartoma",
    "id": "HP:0002444",
    "name": "Hypothalamic hamartoma",
    "definition": "The presence of a hamartoma of the hypothalamus.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-hypothalamus-morphology",
        "name": "Abnormal shape of hypothalamus",
        "url": "https://dantelabs.com/traits/abnormal-hypothalamus-morphology"
      },
      {
        "slug": "cerebral-hamartoma",
        "name": "Cerebral hamartoma",
        "url": "https://dantelabs.com/traits/cerebral-hamartoma"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gli3",
        "symbol": "GLI3",
        "hgnc": "HGNC:4319",
        "name": "GLI family zinc finger 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gli3"
      },
      {
        "slug": "smo",
        "symbol": "SMO",
        "hgnc": "HGNC:11119",
        "name": "smoothened, frizzled class receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smo"
      },
      {
        "slug": "cplane1",
        "symbol": "CPLANE1",
        "hgnc": "HGNC:25801",
        "name": "ciliogenesis and planar polarity effector complex subunit 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cplane1"
      },
      {
        "slug": "man2c1",
        "symbol": "MAN2C1",
        "hgnc": "HGNC:6827",
        "name": "mannosidase alpha class 2C member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/man2c1"
      },
      {
        "slug": "tiam1",
        "symbol": "TIAM1",
        "hgnc": "HGNC:11805",
        "name": "TIAM Rac1 associated GEF 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tiam1"
      },
      {
        "slug": "fam149b1",
        "symbol": "FAM149B1",
        "hgnc": "HGNC:29162",
        "name": "family with sequence similarity 149 member B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam149b1"
      },
      {
        "slug": "kiaa0753",
        "symbol": "KIAA0753",
        "hgnc": "HGNC:29110",
        "name": "KIAA0753",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa0753"
      },
      {
        "slug": "kif7",
        "symbol": "KIF7",
        "hgnc": "HGNC:30497",
        "name": "kinesin family member 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif7"
      },
      {
        "slug": "ofd1",
        "symbol": "OFD1",
        "hgnc": "HGNC:2567",
        "name": "OFD1 centriole and centriolar satellite protein",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ofd1"
      },
      {
        "slug": "pde6d",
        "symbol": "PDE6D",
        "hgnc": "HGNC:8788",
        "name": "phosphodiesterase 6D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde6d"
      },
      {
        "slug": "tctn3",
        "symbol": "TCTN3",
        "hgnc": "HGNC:24519",
        "name": "tectonic family member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tctn3"
      },
      {
        "slug": "tmem216",
        "symbol": "TMEM216",
        "hgnc": "HGNC:25018",
        "name": "transmembrane protein 216",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem216"
      },
      {
        "slug": "tmem231",
        "symbol": "TMEM231",
        "hgnc": "HGNC:37234",
        "name": "transmembrane protein 231",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem231"
      },
      {
        "slug": "topors",
        "symbol": "TOPORS",
        "hgnc": "HGNC:21653",
        "name": "TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/topors"
      },
      {
        "slug": "vps16",
        "symbol": "VPS16",
        "hgnc": "HGNC:14584",
        "name": "VPS16 core subunit of CORVET and HOPS complexes",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps16"
      },
      {
        "slug": "six6",
        "symbol": "SIX6",
        "hgnc": "HGNC:10892",
        "name": "SIX homeobox 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/six6"
      },
      {
        "slug": "sox2",
        "symbol": "SOX2",
        "hgnc": "HGNC:11195",
        "name": "SRY-box transcription factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox2"
      }
    ]
  }
}