{
  "url": "https://dantelabs.com/traits/hypoplastic-helices",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypoplastic-helices",
    "id": "HP:0008589",
    "name": "Hypoplastic helices",
    "definition": "Underdevelopment of the helix, i.e., of the outer rim of the pinna.",
    "synonyms": [
      "Underdeveloped helices"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-ear",
        "name": "Abnormality of the ear",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ear"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-helix-morphology",
        "name": "Abnormal helix morphology",
        "url": "https://dantelabs.com/traits/abnormal-helix-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "hypoplastic-superior-helix",
        "name": "Hypoplastic superior helix",
        "genes": 5,
        "url": "https://dantelabs.com/traits/hypoplastic-superior-helix"
      }
    ],
    "genes": [
      {
        "slug": "hoxa2",
        "symbol": "HOXA2",
        "hgnc": "HGNC:5103",
        "name": "homeobox A2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxa2"
      },
      {
        "slug": "aass",
        "symbol": "AASS",
        "hgnc": "HGNC:17366",
        "name": "aminoadipate-semialdehyde synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aass"
      },
      {
        "slug": "ago2",
        "symbol": "AGO2",
        "hgnc": "HGNC:3263",
        "name": "argonaute RISC catalytic component 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ago2"
      },
      {
        "slug": "foxp1",
        "symbol": "FOXP1",
        "hgnc": "HGNC:3823",
        "name": "forkhead box P1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp1"
      },
      {
        "slug": "pah",
        "symbol": "PAH",
        "hgnc": "HGNC:8582",
        "name": "phenylalanine hydroxylase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pah"
      },
      {
        "slug": "pbx1",
        "symbol": "PBX1",
        "hgnc": "HGNC:8632",
        "name": "PBX homeobox 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pbx1"
      }
    ]
  }
}