{
  "url": "https://dantelabs.com/traits/hyperglycinemia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hyperglycinemia",
    "id": "HP:0002154",
    "name": "Elevated blood glycine levels",
    "label": "Hyperglycinemia",
    "definition": "An elevated concentration of glycine in the blood.",
    "synonyms": [
      "Hyperglycinaemia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-glycine-concentration",
        "name": "Abnormal circulating glycine concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-glycine-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "nonketotic-hyperglycinemia",
        "name": "Nonketotic hyperglycinemia",
        "genes": 4,
        "url": "https://dantelabs.com/traits/nonketotic-hyperglycinemia"
      }
    ],
    "genes": [
      {
        "slug": "bola3",
        "symbol": "BOLA3",
        "hgnc": "HGNC:24415",
        "name": "bolA family member 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/bola3"
      },
      {
        "slug": "cox8a",
        "symbol": "COX8A",
        "hgnc": "HGNC:2294",
        "name": "cytochrome c oxidase subunit 8A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox8a"
      },
      {
        "slug": "gcsh",
        "symbol": "GCSH",
        "hgnc": "HGNC:4208",
        "name": "glycine cleavage system protein H",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gcsh"
      },
      {
        "slug": "glrx5",
        "symbol": "GLRX5",
        "hgnc": "HGNC:20134",
        "name": "glutaredoxin 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glrx5"
      },
      {
        "slug": "iba57",
        "symbol": "IBA57",
        "hgnc": "HGNC:27302",
        "name": "iron-sulfur cluster assembly factor IBA57",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/iba57"
      },
      {
        "slug": "nfs1",
        "symbol": "NFS1",
        "hgnc": "HGNC:15910",
        "name": "NFS1 cysteine desulfurase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfs1"
      },
      {
        "slug": "nfu1",
        "symbol": "NFU1",
        "hgnc": "HGNC:16287",
        "name": "NFU1 iron-sulfur cluster scaffold",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nfu1"
      },
      {
        "slug": "psat1",
        "symbol": "PSAT1",
        "hgnc": "HGNC:19129",
        "name": "phosphoserine aminotransferase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psat1"
      },
      {
        "slug": "aldh4a1",
        "symbol": "ALDH4A1",
        "hgnc": "HGNC:406",
        "name": "aldehyde dehydrogenase 4 family member A1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh4a1"
      },
      {
        "slug": "atp5f1a",
        "symbol": "ATP5F1A",
        "hgnc": "HGNC:823",
        "name": "ATP synthase F1 subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp5f1a"
      },
      {
        "slug": "glyctk",
        "symbol": "GLYCTK",
        "hgnc": "HGNC:24247",
        "name": "glycerate kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glyctk"
      },
      {
        "slug": "lipt2",
        "symbol": "LIPT2",
        "hgnc": "HGNC:37216",
        "name": "lipoyl(octanoyl) transferase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipt2"
      },
      {
        "slug": "pet117",
        "symbol": "PET117",
        "hgnc": "HGNC:40045",
        "name": "PET117 cytochrome c oxidase chaperone",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pet117"
      },
      {
        "slug": "slc7a7",
        "symbol": "SLC7A7",
        "hgnc": "HGNC:11065",
        "name": "solute carrier family 7 member 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc7a7"
      },
      {
        "slug": "isca2",
        "symbol": "ISCA2",
        "hgnc": "HGNC:19857",
        "name": "iron-sulfur cluster assembly 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/isca2"
      },
      {
        "slug": "slc30a10",
        "symbol": "SLC30A10",
        "hgnc": "HGNC:25355",
        "name": "solute carrier family 30 member 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc30a10"
      },
      {
        "slug": "gldc",
        "symbol": "GLDC",
        "hgnc": "HGNC:4313",
        "name": "glycine decarboxylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gldc"
      },
      {
        "slug": "mmaa",
        "symbol": "MMAA",
        "hgnc": "HGNC:18871",
        "name": "metabolism of cobalamin associated A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmaa"
      },
      {
        "slug": "mmab",
        "symbol": "MMAB",
        "hgnc": "HGNC:19331",
        "name": "metabolism of cobalamin associated B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmab"
      },
      {
        "slug": "mmut",
        "symbol": "MMUT",
        "hgnc": "HGNC:7526",
        "name": "methylmalonyl-CoA mutase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmut"
      },
      {
        "slug": "pcca",
        "symbol": "PCCA",
        "hgnc": "HGNC:8653",
        "name": "propionyl-CoA carboxylase subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcca"
      },
      {
        "slug": "pccb",
        "symbol": "PCCB",
        "hgnc": "HGNC:8654",
        "name": "propionyl-CoA carboxylase subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pccb"
      },
      {
        "slug": "slc36a2",
        "symbol": "SLC36A2",
        "hgnc": "HGNC:18762",
        "name": "solute carrier family 36 member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc36a2"
      },
      {
        "slug": "slc6a18",
        "symbol": "SLC6A18",
        "hgnc": "HGNC:26441",
        "name": "solute carrier family 6 member 18",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a18"
      },
      {
        "slug": "slc6a19",
        "symbol": "SLC6A19",
        "hgnc": "HGNC:27960",
        "name": "solute carrier family 6 member 19",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a19"
      },
      {
        "slug": "slc6a20",
        "symbol": "SLC6A20",
        "hgnc": "HGNC:30927",
        "name": "solute carrier family 6 member 20",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a20"
      },
      {
        "slug": "slc6a9",
        "symbol": "SLC6A9",
        "hgnc": "HGNC:11056",
        "name": "solute carrier family 6 member 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a9"
      },
      {
        "slug": "suclg1",
        "symbol": "SUCLG1",
        "hgnc": "HGNC:11449",
        "name": "succinate-CoA ligase GDP/ADP-forming subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/suclg1"
      }
    ]
  }
}