{
  "url": "https://dantelabs.com/traits/hand-monodactyly",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "hand-monodactyly",
    "id": "HP:0004058",
    "name": "Hand monodactyly",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "finger-aplasia",
        "name": "Absent fingers",
        "url": "https://dantelabs.com/traits/finger-aplasia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "tbx5",
        "symbol": "TBX5",
        "hgnc": "HGNC:11604",
        "name": "T-box transcription factor 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx5"
      },
      {
        "slug": "bhlha9",
        "symbol": "BHLHA9",
        "hgnc": "HGNC:35126",
        "name": "basic helix-loop-helix family member a9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bhlha9"
      },
      {
        "slug": "btrc",
        "symbol": "BTRC",
        "hgnc": "HGNC:1144",
        "name": "beta-transducin repeat containing E3 ubiquitin protein ligase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btrc"
      },
      {
        "slug": "chd7",
        "symbol": "CHD7",
        "hgnc": "HGNC:20626",
        "name": "chromodomain helicase DNA binding protein 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd7"
      },
      {
        "slug": "dlx5",
        "symbol": "DLX5",
        "hgnc": "HGNC:2918",
        "name": "distal-less homeobox 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlx5"
      },
      {
        "slug": "dlx6",
        "symbol": "DLX6",
        "hgnc": "HGNC:2919",
        "name": "distal-less homeobox 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlx6"
      },
      {
        "slug": "eps15l1",
        "symbol": "EPS15L1",
        "hgnc": "HGNC:24634",
        "name": "epidermal growth factor receptor pathway substrate 15 like 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eps15l1"
      },
      {
        "slug": "fbxw4",
        "symbol": "FBXW4",
        "hgnc": "HGNC:10847",
        "name": "F-box and WD repeat domain containing 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxw4"
      },
      {
        "slug": "sem1",
        "symbol": "SEM1",
        "hgnc": "HGNC:10845",
        "name": "SEM1 26S proteasome subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sem1"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "wnt10b",
        "symbol": "WNT10B",
        "hgnc": "HGNC:12775",
        "name": "Wnt family member 10B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10b"
      }
    ]
  }
}