{
  "url": "https://dantelabs.com/traits/developmental-stagnation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "developmental-stagnation",
    "id": "HP:0007281",
    "name": "Developmental stagnation",
    "definition": "A cessation of the development of a child in the areas of motor skills, speech and language, cognitive skills, and social and/or emotional skills.",
    "synonyms": [
      "Developmental arrest"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "neurodevelopmental-abnormality",
        "name": "Neurodevelopmental abnormality",
        "url": "https://dantelabs.com/traits/neurodevelopmental-abnormality"
      }
    ],
    "narrower": [
      {
        "slug": "developmental-stagnation-at-onset-of-seizures",
        "name": "Developmental stagnation at onset of seizures",
        "genes": 2,
        "url": "https://dantelabs.com/traits/developmental-stagnation-at-onset-of-seizures"
      }
    ],
    "genes": [
      {
        "slug": "acer3",
        "symbol": "ACER3",
        "hgnc": "HGNC:16066",
        "name": "alkaline ceramidase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acer3"
      },
      {
        "slug": "gabbr2",
        "symbol": "GABBR2",
        "hgnc": "HGNC:4507",
        "name": "gamma-aminobutyric acid type B receptor subunit 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gabbr2"
      },
      {
        "slug": "ptpn23",
        "symbol": "PTPN23",
        "hgnc": "HGNC:14406",
        "name": "protein tyrosine phosphatase non-receptor type 23",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn23"
      },
      {
        "slug": "mcoln1",
        "symbol": "MCOLN1",
        "hgnc": "HGNC:13356",
        "name": "mucolipin TRP cation channel 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mcoln1"
      },
      {
        "slug": "acan",
        "symbol": "ACAN",
        "hgnc": "HGNC:319",
        "name": "aggrecan",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acan"
      },
      {
        "slug": "phgdh",
        "symbol": "PHGDH",
        "hgnc": "HGNC:8923",
        "name": "phosphoglycerate dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phgdh"
      },
      {
        "slug": "rars1",
        "symbol": "RARS1",
        "hgnc": "HGNC:9870",
        "name": "arginyl-tRNA synthetase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rars1"
      },
      {
        "slug": "rnh1",
        "symbol": "RNH1",
        "hgnc": "HGNC:10074",
        "name": "ribonuclease/angiogenin inhibitor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnh1"
      },
      {
        "slug": "smpd1",
        "symbol": "SMPD1",
        "hgnc": "HGNC:11120",
        "name": "sphingomyelin phosphodiesterase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smpd1"
      },
      {
        "slug": "cdkl5",
        "symbol": "CDKL5",
        "hgnc": "HGNC:11411",
        "name": "cyclin dependent kinase like 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkl5"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "ntng1",
        "symbol": "NTNG1",
        "hgnc": "HGNC:23319",
        "name": "netrin G1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ntng1"
      },
      {
        "slug": "polr2a",
        "symbol": "POLR2A",
        "hgnc": "HGNC:9187",
        "name": "RNA polymerase II subunit A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr2a"
      },
      {
        "slug": "smc1a",
        "symbol": "SMC1A",
        "hgnc": "HGNC:11111",
        "name": "structural maintenance of chromosomes 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc1a"
      },
      {
        "slug": "glb1",
        "symbol": "GLB1",
        "hgnc": "HGNC:4298",
        "name": "galactosidase beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glb1"
      },
      {
        "slug": "nup62",
        "symbol": "NUP62",
        "hgnc": "HGNC:8066",
        "name": "nucleoporin 62",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup62"
      },
      {
        "slug": "scn1b",
        "symbol": "SCN1B",
        "hgnc": "HGNC:10586",
        "name": "sodium voltage-gated channel beta subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1b"
      },
      {
        "slug": "vps11",
        "symbol": "VPS11",
        "hgnc": "HGNC:14583",
        "name": "VPS11 core subunit of CORVET and HOPS complexes",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps11"
      },
      {
        "slug": "znhit3",
        "symbol": "ZNHIT3",
        "hgnc": "HGNC:12309",
        "name": "zinc finger HIT-type containing 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znhit3"
      }
    ]
  }
}