{
  "url": "https://dantelabs.com/traits/broad-columella",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "broad-columella",
    "id": "HP:0010761",
    "name": "Broad columella",
    "definition": "Increased width of the columella.",
    "synonyms": [
      "Columella, broad",
      "Columella, wide",
      "Fullness of columella",
      "Increased width of columella"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-columella-morphology",
        "name": "Abnormal columella morphology",
        "url": "https://dantelabs.com/traits/abnormal-columella-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "exosc2",
        "symbol": "EXOSC2",
        "hgnc": "HGNC:17097",
        "name": "exosome component 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/exosc2"
      },
      {
        "slug": "ppp1r21",
        "symbol": "PPP1R21",
        "hgnc": "HGNC:30595",
        "name": "protein phosphatase 1 regulatory subunit 21",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp1r21"
      },
      {
        "slug": "rps6ka3",
        "symbol": "RPS6KA3",
        "hgnc": "HGNC:10432",
        "name": "ribosomal protein S6 kinase A3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps6ka3"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "alx4",
        "symbol": "ALX4",
        "hgnc": "HGNC:450",
        "name": "ALX homeobox 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alx4"
      },
      {
        "slug": "ckap2l",
        "symbol": "CKAP2L",
        "hgnc": "HGNC:26877",
        "name": "cytoskeleton associated protein 2L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ckap2l"
      },
      {
        "slug": "fli1",
        "symbol": "FLI1",
        "hgnc": "HGNC:3749",
        "name": "Fli-1 proto-oncogene, ETS transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fli1"
      },
      {
        "slug": "hdac4",
        "symbol": "HDAC4",
        "hgnc": "HGNC:14063",
        "name": "histone deacetylase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hdac4"
      },
      {
        "slug": "pik3c2a",
        "symbol": "PIK3C2A",
        "hgnc": "HGNC:8971",
        "name": "phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pik3c2a"
      },
      {
        "slug": "rdh11",
        "symbol": "RDH11",
        "hgnc": "HGNC:17964",
        "name": "retinol dehydrogenase 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rdh11"
      },
      {
        "slug": "tshz3",
        "symbol": "TSHZ3",
        "hgnc": "HGNC:30700",
        "name": "teashirt zinc finger homeobox 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshz3"
      },
      {
        "slug": "cwc27",
        "symbol": "CWC27",
        "hgnc": "HGNC:10664",
        "name": "CWC27 spliceosome associated cyclophilin",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cwc27"
      },
      {
        "slug": "h4c5",
        "symbol": "H4C5",
        "hgnc": "HGNC:4790",
        "name": "H4 clustered histone 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h4c5"
      },
      {
        "slug": "atp6v1e1",
        "symbol": "ATP6V1E1",
        "hgnc": "HGNC:857",
        "name": "ATPase H+ transporting V1 subunit E1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1e1"
      },
      {
        "slug": "zswim6",
        "symbol": "ZSWIM6",
        "hgnc": "HGNC:29316",
        "name": "zinc finger SWIM-type containing 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zswim6"
      }
    ]
  }
}