{
  "url": "https://dantelabs.com/traits/anasarca",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "anasarca",
    "id": "HP:0012050",
    "name": "Anasarca",
    "definition": "An extreme form of generalized edema with widespread and massive edema due to effusion of fluid into the extracellular space.",
    "synonyms": [
      "Extreme generalised oedema",
      "Extreme generalized edema"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "generalized-edema",
        "name": "Generalized edema",
        "url": "https://dantelabs.com/traits/generalized-edema"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "farsb",
        "symbol": "FARSB",
        "hgnc": "HGNC:17800",
        "name": "phenylalanyl-tRNA synthetase subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/farsb"
      },
      {
        "slug": "nphs1",
        "symbol": "NPHS1",
        "hgnc": "HGNC:7908",
        "name": "NPHS1 adhesion molecule, nephrin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nphs1"
      },
      {
        "slug": "plvap",
        "symbol": "PLVAP",
        "hgnc": "HGNC:13635",
        "name": "plasmalemma vesicle associated protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plvap"
      },
      {
        "slug": "def6",
        "symbol": "DEF6",
        "hgnc": "HGNC:2760",
        "name": "DEF6 guanine nucleotide exchange factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/def6"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "scarb2",
        "symbol": "SCARB2",
        "hgnc": "HGNC:1665",
        "name": "scavenger receptor class B member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarb2"
      },
      {
        "slug": "dpagt1",
        "symbol": "DPAGT1",
        "hgnc": "HGNC:2995",
        "name": "dolichyl-phosphate N-acetylglucosaminephosphotransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpagt1"
      },
      {
        "slug": "prkag2",
        "symbol": "PRKAG2",
        "hgnc": "HGNC:9386",
        "name": "protein kinase AMP-activated non-catalytic subunit gamma 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkag2"
      },
      {
        "slug": "pmm2",
        "symbol": "PMM2",
        "hgnc": "HGNC:9115",
        "name": "phosphomannomutase 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmm2"
      },
      {
        "slug": "ubr1",
        "symbol": "UBR1",
        "hgnc": "HGNC:16808",
        "name": "ubiquitin protein ligase E3 component n-recognin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubr1"
      }
    ]
  }
}