{
  "url": "https://dantelabs.com/traits/acute-hyperammonemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "acute-hyperammonemia",
    "id": "HP:0008281",
    "name": "Acute hyperammonemia",
    "definition": "An increased concentration of ammonia in the blood with sudden onset.",
    "synonyms": [
      "Hyperammonemia, acute"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "hyperammonemia",
        "name": "High blood ammonia levels",
        "url": "https://dantelabs.com/traits/hyperammonemia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "slc25a13",
        "symbol": "SLC25A13",
        "hgnc": "HGNC:10983",
        "name": "solute carrier family 25 member 13",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a13"
      },
      {
        "slug": "nags",
        "symbol": "NAGS",
        "hgnc": "HGNC:17996",
        "name": "N-acetylglutamate synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nags"
      },
      {
        "slug": "mccc1",
        "symbol": "MCCC1",
        "hgnc": "HGNC:6936",
        "name": "methylcrotonyl-CoA carboxylase subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mccc1"
      },
      {
        "slug": "mccc2",
        "symbol": "MCCC2",
        "hgnc": "HGNC:6937",
        "name": "methylcrotonyl-CoA carboxylase subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mccc2"
      }
    ]
  }
}