{
  "url": "https://dantelabs.com/traits/abnormal-synaptic-transmission",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-synaptic-transmission",
    "id": "HP:0012535",
    "name": "Abnormal synaptic transmission",
    "definition": "An anomaly in the communication from a neuron to a target across a synapse. This is a four step process, comprising (i) synthesis and storage of neurotransmitters; (ii) neurotransmitter release; (iii) activation of postsynaptic receptors by the neurotransmitter; and (iv) inactivation of the neurotransmitter. Thus, this term is defined as an anomaly of neurotransmitter metabolic process.",
    "synonyms": [
      "Abnormality of neurotransmitter metabolism"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nervous-system-physiology",
        "name": "Abnormal nervous system physiology",
        "url": "https://dantelabs.com/traits/abnormal-nervous-system-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-peripheral-nervous-system-synaptic-transmission",
        "name": "Abnormal peripheral nervous system synaptic transmission",
        "genes": 5,
        "url": "https://dantelabs.com/traits/abnormal-peripheral-nervous-system-synaptic-transmission"
      }
    ],
    "genes": []
  }
}