{
  "url": "https://dantelabs.com/traits/abnormal-platelet-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-platelet-morphology",
    "id": "HP:0011875",
    "name": "Abnormal shape of platelets",
    "label": "Abnormal platelet morphology",
    "definition": "An anomaly in platelet form, ultrastructure, or intracellular organelles.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-thrombocytes",
        "name": "Platelet abnormalities",
        "url": "https://dantelabs.com/traits/abnormality-of-thrombocytes"
      }
    ],
    "narrower": [
      {
        "slug": "platelet-anisocytosis",
        "name": "Platelet anisocytosis",
        "genes": 11,
        "url": "https://dantelabs.com/traits/platelet-anisocytosis"
      },
      {
        "slug": "abnormal-platelet-count",
        "name": "Abnormal platelet count",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-platelet-count"
      },
      {
        "slug": "abnormal-platelet-granules",
        "name": "Abnormal platelet granules",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-platelet-granules"
      },
      {
        "slug": "abnormal-platelet-volume",
        "name": "Abnormal platelet volume",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-platelet-volume"
      }
    ],
    "genes": [
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "mpl",
        "symbol": "MPL",
        "hgnc": "HGNC:7217",
        "name": "MPL proto-oncogene, thrombopoietin receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpl"
      },
      {
        "slug": "sh2b3",
        "symbol": "SH2B3",
        "hgnc": "HGNC:29605",
        "name": "SH2B adaptor protein 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh2b3"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/was"
      },
      {
        "slug": "sc5d",
        "symbol": "SC5D",
        "hgnc": "HGNC:10547",
        "name": "sterol-C5-desaturase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sc5d"
      }
    ]
  }
}