{
  "url": "https://dantelabs.com/traits/abnormal-platelet-aggregation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-platelet-aggregation",
    "id": "HP:0030402",
    "name": "Abnormal platelet aggregation",
    "definition": "An abnormality in the rate and degree to which platelets aggregate after the addition of an agonist that stimulates platelet clumping. Platelet aggregation is measured using aggregometer to measure the optical density of platelet-rich plasma, whereby platelet aggregation causes the plasma to become more transparent.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-platelet-function",
        "name": "Abnormal platelet function",
        "url": "https://dantelabs.com/traits/abnormal-platelet-function"
      }
    ],
    "narrower": [
      {
        "slug": "impaired-platelet-aggregation",
        "name": "Impaired platelet aggregation",
        "genes": 12,
        "url": "https://dantelabs.com/traits/impaired-platelet-aggregation"
      }
    ],
    "genes": [
      {
        "slug": "vipas39",
        "symbol": "VIPAS39",
        "hgnc": "HGNC:20347",
        "name": "VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vipas39"
      },
      {
        "slug": "vps33b",
        "symbol": "VPS33B",
        "hgnc": "HGNC:12712",
        "name": "VPS33B late endosome and lysosome associated",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps33b"
      },
      {
        "slug": "gucy1a1",
        "symbol": "GUCY1A1",
        "hgnc": "HGNC:4685",
        "name": "guanylate cyclase 1 soluble subunit alpha 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gucy1a1"
      }
    ]
  }
}