{
  "url": "https://dantelabs.com/traits/abnormal-lip-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-lip-morphology",
    "id": "HP:0000159",
    "name": "Abnormal lip",
    "label": "Abnormal lip morphology",
    "definition": "An abnormality of the lip.",
    "synonyms": [
      "Abnormality of the lip",
      "Anomaly of lip",
      "Deformity of lip",
      "Lip abnormality",
      "Malformation of lip"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-oral-cavity-morphology",
        "name": "Abnormality of the oral cavity",
        "url": "https://dantelabs.com/traits/abnormal-oral-cavity-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "thick-vermilion-border",
        "name": "Full lips",
        "genes": 171,
        "url": "https://dantelabs.com/traits/thick-vermilion-border"
      },
      {
        "slug": "thin-vermilion-border",
        "name": "Decreased volume of lip",
        "genes": 143,
        "url": "https://dantelabs.com/traits/thin-vermilion-border"
      },
      {
        "slug": "cleft-lip",
        "name": "Cleft lip",
        "genes": 92,
        "url": "https://dantelabs.com/traits/cleft-lip"
      },
      {
        "slug": "cheilitis",
        "name": "Inflammation of the lips",
        "genes": 47,
        "url": "https://dantelabs.com/traits/cheilitis"
      },
      {
        "slug": "eclabion",
        "name": "Outward turned lips",
        "genes": 30,
        "url": "https://dantelabs.com/traits/eclabion"
      },
      {
        "slug": "lip-pit",
        "name": "Lip pit",
        "genes": 11,
        "url": "https://dantelabs.com/traits/lip-pit"
      },
      {
        "slug": "swollen-lip",
        "name": "Swollen lip",
        "genes": 7,
        "url": "https://dantelabs.com/traits/swollen-lip"
      },
      {
        "slug": "abnormal-upper-lip-morphology",
        "name": "Abnormality of upper lip",
        "genes": 6,
        "url": "https://dantelabs.com/traits/abnormal-upper-lip-morphology"
      },
      {
        "slug": "lip-telangiectasia",
        "name": "Spider veins of the lip",
        "genes": 6,
        "url": "https://dantelabs.com/traits/lip-telangiectasia"
      },
      {
        "slug": "chapped-lip",
        "name": "Chapped lip",
        "genes": 3,
        "url": "https://dantelabs.com/traits/chapped-lip"
      },
      {
        "slug": "lip-fissure",
        "name": "Lip fissure",
        "genes": 3,
        "url": "https://dantelabs.com/traits/lip-fissure"
      },
      {
        "slug": "lip-freckle",
        "name": "Lip freckle",
        "genes": 1,
        "url": "https://dantelabs.com/traits/lip-freckle"
      },
      {
        "slug": "abnormal-lip-pigmentation",
        "name": "Abnormal lip pigmentation",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-lip-pigmentation"
      },
      {
        "slug": "abnormal-lower-lip-morphology",
        "name": "Abnormality of lower lip",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-lower-lip-morphology"
      },
      {
        "slug": "vascular-malformation-of-the-lip",
        "name": "Vascular malformation of the lip",
        "genes": 0,
        "url": "https://dantelabs.com/traits/vascular-malformation-of-the-lip"
      }
    ],
    "genes": [
      {
        "slug": "clec7a",
        "symbol": "CLEC7A",
        "hgnc": "HGNC:14558",
        "name": "C-type lectin domain containing 7A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clec7a"
      },
      {
        "slug": "cplx1",
        "symbol": "CPLX1",
        "hgnc": "HGNC:2309",
        "name": "complexin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cplx1"
      },
      {
        "slug": "ctbp1",
        "symbol": "CTBP1",
        "hgnc": "HGNC:2494",
        "name": "C-terminal binding protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctbp1"
      },
      {
        "slug": "il17f",
        "symbol": "IL17F",
        "hgnc": "HGNC:16404",
        "name": "interleukin 17F",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17f"
      },
      {
        "slug": "il17ra",
        "symbol": "IL17RA",
        "hgnc": "HGNC:5985",
        "name": "interleukin 17 receptor A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17ra"
      },
      {
        "slug": "il17rc",
        "symbol": "IL17RC",
        "hgnc": "HGNC:18358",
        "name": "interleukin 17 receptor C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17rc"
      },
      {
        "slug": "letm1",
        "symbol": "LETM1",
        "hgnc": "HGNC:6556",
        "name": "leucine zipper and EF-hand containing transmembrane protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/letm1"
      },
      {
        "slug": "nelfa",
        "symbol": "NELFA",
        "hgnc": "HGNC:12768",
        "name": "negative elongation factor complex member A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nelfa"
      },
      {
        "slug": "nsd2",
        "symbol": "NSD2",
        "hgnc": "HGNC:12766",
        "name": "nuclear receptor binding SET domain protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsd2"
      },
      {
        "slug": "pigg",
        "symbol": "PIGG",
        "hgnc": "HGNC:25985",
        "name": "phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigg"
      },
      {
        "slug": "rin2",
        "symbol": "RIN2",
        "hgnc": "HGNC:18750",
        "name": "Ras and Rab interactor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rin2"
      },
      {
        "slug": "traf3ip2",
        "symbol": "TRAF3IP2",
        "hgnc": "HGNC:1343",
        "name": "TRAF3 interacting protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3ip2"
      },
      {
        "slug": "smad4",
        "symbol": "SMAD4",
        "hgnc": "HGNC:6770",
        "name": "SMAD family member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad4"
      },
      {
        "slug": "ube3b",
        "symbol": "UBE3B",
        "hgnc": "HGNC:13478",
        "name": "ubiquitin protein ligase E3B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube3b"
      }
    ]
  }
}