{
  "url": "https://dantelabs.com/traits/abnormal-circulating-t4-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-t4-concentration",
    "id": "HP:0031505",
    "name": "Abnormal circulating T4 concentration",
    "definition": "A deviation from the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3).",
    "synonyms": [
      "Abnormal circulating T4 level",
      "Abnormal circulating thyroxine level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-thyroid-hormone-concentration",
        "name": "Abnormal circulating thyroid hormone concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-thyroid-hormone-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-circulating-t4-concentration",
        "name": "Decreased circulating T4 concentration",
        "genes": 23,
        "url": "https://dantelabs.com/traits/decreased-circulating-t4-concentration"
      },
      {
        "slug": "increased-circulating-t4-concentration",
        "name": "Increased circulating T4 concentration",
        "genes": 4,
        "url": "https://dantelabs.com/traits/increased-circulating-t4-concentration"
      }
    ],
    "genes": []
  }
}