{
  "url": "https://dantelabs.com/traits/abnormal-circulating-folate-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-folate-concentration",
    "id": "HP:0040087",
    "name": "Abnormal circulating folate concentration",
    "definition": "Any deviation from the normal concentration of folate in the blood circulation.",
    "synonyms": [
      "Abnormal blood folate concentration",
      "Abnormal serum folate",
      "Abnormality of folate in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-vitamin-concentration",
        "name": "Abnormal circulating vitamin concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-vitamin-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-circulating-folate-concentration",
        "name": "Folate deficiency",
        "genes": 5,
        "url": "https://dantelabs.com/traits/decreased-circulating-folate-concentration"
      },
      {
        "slug": "abnormal-circulating-5-methyltetrahydrofolate-concentration",
        "name": "Abnormal circulating 5-methyltetrahydrofolate concentration",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-circulating-5-methyltetrahydrofolate-concentration"
      },
      {
        "slug": "increased-circulating-folate-concentration",
        "name": "Increased circulating folate concentration",
        "genes": 2,
        "url": "https://dantelabs.com/traits/increased-circulating-folate-concentration"
      }
    ],
    "genes": [
      {
        "slug": "ftcd",
        "symbol": "FTCD",
        "hgnc": "HGNC:3974",
        "name": "formimidoyltransferase cyclodeaminase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ftcd"
      }
    ]
  }
}