{
  "url": "https://dantelabs.com/el/genes/tubb8",
  "gene": {
    "slug": "tubb8",
    "symbol": "TUBB8",
    "name": "tubulin beta 8 class VIII",
    "hgnc": "HGNC:20773",
    "summary": null,
    "location": "10p15.3",
    "locusType": "gene with protein product",
    "aliases": [
      "bA631M21.2"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000261456",
    "entrezId": 347688,
    "omim": [
      "616768"
    ],
    "uniprot": [
      "Q3ZCM7"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "10",
      "start": 46888,
      "end": 49296,
      "strand": "-",
      "ensemblTranscript": "ENST00000568584.6",
      "refseqTranscript": "NM_177987.3",
      "ensemblProtein": "ENSP00000456206.2",
      "refseqProtein": "NP_817124.1",
      "exons": [
        {
          "start": 46888,
          "end": 48114
        },
        {
          "start": 48615,
          "end": 48725
        },
        {
          "start": 48804,
          "end": 48912
        },
        {
          "start": 49182,
          "end": 49296
        }
      ],
      "cds": {
        "start": 47057,
        "end": 49238
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "10",
      "start": 92828,
      "end": 120103,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 1,
      "end": 548091,
      "genes": [
        {
          "symbol": "ZMYND11",
          "ensemblId": "ENSG00000015171",
          "biotype": "protein_coding",
          "start": 130088,
          "end": 254771,
          "strand": "+",
          "slug": "zmynd11"
        },
        {
          "symbol": "DIP2C",
          "ensemblId": "ENSG00000151240",
          "biotype": "protein_coding",
          "start": 274201,
          "end": 689937,
          "strand": "-",
          "slug": "dip2c"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "female-infertility",
        "name": "Γυναικεία υπογονιμότητα",
        "diseases": [
          {
            "mondoId": "MONDO:0014769",
            "name": "κληρονομική διαταραχή της ωρίμανσης των ωοκυττάρων",
            "genes": 17,
            "inheritance": null,
            "description": null,
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant",
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/female-infertility"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-meiosis",
        "name": "Abnormal meiosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/abnormal-meiosis"
      },
      {
        "slug": "abnormal-oocyte-morphology",
        "name": "Abnormal oocyte morphology",
        "systems": [
          "abnormal-cellular-phenotype"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-oocyte-morphology"
      },
      {
        "slug": "abnormal-spermatogenesis",
        "name": "Abnormal sperm development",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/abnormal-spermatogenesis"
      },
      {
        "slug": "female-infertility",
        "name": "Female infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/female-infertility"
      },
      {
        "slug": "metaphase-i-oocyte-maturation-arrest",
        "name": "Metaphase I oocyte maturation arrest",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/metaphase-i-oocyte-maturation-arrest"
      },
      {
        "slug": "polycystic-ovaries",
        "name": "Polycystic ovaries",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/polycystic-ovaries"
      }
    ],
    "related": [
      {
        "slug": "btg4",
        "symbol": "BTG4",
        "name": "BTG anti-proliferation factor 4",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/btg4"
      },
      {
        "slug": "cdc20",
        "symbol": "CDC20",
        "name": "cell division cycle 20",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/cdc20"
      },
      {
        "slug": "kpna7",
        "symbol": "KPNA7",
        "name": "karyopherin subunit alpha 7",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/kpna7"
      },
      {
        "slug": "mos",
        "symbol": "MOS",
        "name": "MOS proto-oncogene, serine/threonine kinase",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/mos"
      },
      {
        "slug": "nlrp2",
        "symbol": "NLRP2",
        "name": "NLR family pyrin domain containing 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/nlrp2"
      },
      {
        "slug": "nlrp5",
        "symbol": "NLRP5",
        "name": "NLR family pyrin domain containing 5",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/nlrp5"
      },
      {
        "slug": "padi6",
        "symbol": "PADI6",
        "name": "peptidyl arginine deiminase 6",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/padi6"
      },
      {
        "slug": "panx1",
        "symbol": "PANX1",
        "name": "pannexin 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/panx1"
      },
      {
        "slug": "patl2",
        "symbol": "PATL2",
        "name": "PAT1 homolog 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/patl2"
      },
      {
        "slug": "rec114",
        "symbol": "REC114",
        "name": "REC114 meiotic recombination protein",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/rec114"
      },
      {
        "slug": "trip13",
        "symbol": "TRIP13",
        "name": "thyroid hormone receptor interactor 13",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/trip13"
      },
      {
        "slug": "tuba4a",
        "symbol": "TUBA4A",
        "name": "tubulin alpha 4a",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/tuba4a"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}