{
  "url": "https://dantelabs.com/el/genes/trpm6",
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    "name": "transient receptor potential cation channel subfamily M member 6",
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    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "9",
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    "neighbourhood": {
      "release": "116",
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      "genes": [
        {
          "symbol": "RORB",
          "ensemblId": "ENSG00000198963",
          "biotype": "protein_coding",
          "start": 74497329,
          "end": 74693177,
          "strand": "+",
          "slug": "rorb"
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        {
          "symbol": "C9orf40",
          "ensemblId": "ENSG00000135045",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "c9orf40"
        },
        {
          "symbol": "CARNMT1",
          "ensemblId": "ENSG00000156017",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "carnmt1"
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        {
          "symbol": "NMRK1",
          "ensemblId": "ENSG00000106733",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "nmrk1"
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        {
          "symbol": "OSTF1",
          "ensemblId": "ENSG00000134996",
          "biotype": "protein_coding",
          "start": 75088421,
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          "strand": "+",
          "slug": "ostf1"
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "familial-hypomagnesemia",
        "name": "Οικογενής υπομαγνησιαιμία",
        "diseases": [
          {
            "mondoId": "MONDO:0018100",
            "name": "Οικογενής πρωτοπαθής υπομαγνησιαιμία",
            "genes": 9,
            "inheritance": null,
            "description": "Ομάδα κληρονομικών διαταραχών απώλειας μαγνησίου που προκαλούνται από μεταλλάξεις σε γονίδια όπως τα CLDN16, CLDN19, TRPM6, CNNM2 και FXYD2· οι μορφές που σχετίζονται με τα CLDN16 και CLDN19 μπορεί να εξελιχθούν σε χρόνια νεφρική νόσο.",
            "management": "Η συμπληρωματική χορήγηση μαγνησίου μπορεί να ελέγξει τα συμπτώματα, και ορισμένες μορφές απαιτούν παρακολούθηση της νεφρικής λειτουργίας και της όρασης.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "Natera",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/familial-hypomagnesemia"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "tetany",
        "name": "Intermittent involuntary muscle spasm",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/tetany"
      },
      {
        "slug": "hypocalcemia",
        "name": "Low blood calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypocalcemia"
      },
      {
        "slug": "hypomagnesemia",
        "name": "Low blood magnesium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypomagnesemia"
      },
      {
        "slug": "muscle-spasm",
        "name": "Muscle spasm",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/muscle-spasm"
      }
    ],
    "related": [
      {
        "slug": "atp1a1",
        "symbol": "ATP1A1",
        "name": "ATPase Na+/K+ transporting subunit alpha 1",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/atp1a1"
      },
      {
        "slug": "cldn16",
        "symbol": "CLDN16",
        "name": "claudin 16",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/cldn16"
      },
      {
        "slug": "cldn19",
        "symbol": "CLDN19",
        "name": "claudin 19",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/cldn19"
      },
      {
        "slug": "cnnm2",
        "symbol": "CNNM2",
        "name": "cyclin and CBS domain divalent metal cation transport mediator 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/cnnm2"
      },
      {
        "slug": "fxyd2",
        "symbol": "FXYD2",
        "name": "FXYD domain containing ion transport regulator 2",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/fxyd2"
      },
      {
        "slug": "rragd",
        "symbol": "RRAGD",
        "name": "Ras related GTP binding D",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/rragd"
      },
      {
        "slug": "trpm7",
        "symbol": "TRPM7",
        "name": "transient receptor potential cation channel subfamily M member 7",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/trpm7"
      },
      {
        "slug": "trpv6",
        "symbol": "TRPV6",
        "name": "transient receptor potential cation channel subfamily V member 6",
        "shared": 1,
        "url": "https://dantelabs.com/el/genes/trpv6"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}