{
  "url": "https://dantelabs.com/el/genes/tpp1",
  "gene": {
    "slug": "tpp1",
    "symbol": "TPP1",
    "name": "tripeptidyl peptidase 1",
    "hgnc": "HGNC:2073",
    "summary": null,
    "location": "11p15.4",
    "locusType": "gene with protein product",
    "aliases": [
      "LPIC",
      "TPP-1"
    ],
    "previousSymbols": [
      "CLN2",
      "SCAR7"
    ],
    "ensemblId": "ENSG00000166340",
    "entrezId": 1200,
    "omim": [
      "607998"
    ],
    "uniprot": [
      "O14773"
    ],
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      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "11",
      "start": 6612768,
      "end": 6619422,
      "strand": "-",
      "ensemblTranscript": "ENST00000299427.12",
      "refseqTranscript": "NM_000391.4",
      "ensemblProtein": "ENSP00000299427.6",
      "refseqProtein": "NP_000382.3",
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        {
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      ],
      "cds": {
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        "end": 6619400
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "11",
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      "end": 6640692,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
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      "end": 7116094,
      "genes": [
        {
          "symbol": "OR52B2",
          "ensemblId": "ENSG00000255307",
          "biotype": "protein_coding",
          "start": 6169355,
          "end": 6170326,
          "strand": "-",
          "slug": "or52b2"
        },
        {
          "symbol": "OR52W1",
          "ensemblId": "ENSG00000175485",
          "biotype": "protein_coding",
          "start": 6199224,
          "end": 6200186,
          "strand": "+",
          "slug": "or52w1"
        },
        {
          "symbol": "C11orf42",
          "ensemblId": "ENSG00000180878",
          "biotype": "protein_coding",
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          "end": 6211135,
          "strand": "+",
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        },
        {
          "symbol": "FHIP1B",
          "ensemblId": "ENSG00000051009",
          "biotype": "protein_coding",
          "start": 6211334,
          "end": 6234711,
          "strand": "-",
          "slug": "fhip1b"
        },
        {
          "symbol": "CNGA4",
          "ensemblId": "ENSG00000132259",
          "biotype": "protein_coding",
          "start": 6234765,
          "end": 6245922,
          "strand": "+",
          "slug": "cnga4"
        },
        {
          "symbol": "CCKBR",
          "ensemblId": "ENSG00000110148",
          "biotype": "protein_coding",
          "start": 6259698,
          "end": 6272127,
          "strand": "+",
          "slug": "cckbr"
        },
        {
          "symbol": "CAVIN3",
          "ensemblId": "ENSG00000170955",
          "biotype": "protein_coding",
          "start": 6318946,
          "end": 6320622,
          "strand": "-",
          "slug": "cavin3"
        },
        {
          "symbol": "SMPD1",
          "ensemblId": "ENSG00000166311",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "smpd1"
        },
        {
          "symbol": "APBB1",
          "ensemblId": "ENSG00000166313",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "apbb1"
        },
        {
          "symbol": "HPX",
          "ensemblId": "ENSG00000110169",
          "biotype": "protein_coding",
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          "end": 6442617,
          "strand": "-",
          "slug": "hpx"
        },
        {
          "symbol": "TRIM3",
          "ensemblId": "ENSG00000110171",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "trim3"
        },
        {
          "symbol": "ARFIP2",
          "ensemblId": "ENSG00000132254",
          "biotype": "protein_coding",
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          "end": 6481479,
          "strand": "-",
          "slug": "arfip2"
        },
        {
          "symbol": "TIMM10B",
          "ensemblId": "ENSG00000132286",
          "biotype": "protein_coding",
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          "slug": "timm10b"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000283977",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "RRP8",
          "ensemblId": "ENSG00000132275",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "rrp8"
        },
        {
          "symbol": "DNHD1",
          "ensemblId": "ENSG00000179532",
          "biotype": "protein_coding",
          "start": 6497260,
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          "strand": "+",
          "slug": "dnhd1"
        },
        {
          "symbol": "ILK",
          "ensemblId": "ENSG00000166333",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "ilk"
        },
        {
          "symbol": "TAF10",
          "ensemblId": "ENSG00000166337",
          "biotype": "protein_coding",
          "start": 6606294,
          "end": 6612539,
          "strand": "-",
          "slug": "taf10"
        },
        {
          "symbol": "DCHS1",
          "ensemblId": "ENSG00000166341",
          "biotype": "protein_coding",
          "start": 6621330,
          "end": 6655834,
          "strand": "-",
          "slug": "dchs1"
        },
        {
          "symbol": "MRPL17",
          "ensemblId": "ENSG00000158042",
          "biotype": "protein_coding",
          "start": 6680364,
          "end": 6683411,
          "strand": "-",
          "slug": "mrpl17"
        },
        {
          "symbol": "OR2AG2",
          "ensemblId": "ENSG00000188124",
          "biotype": "protein_coding",
          "start": 6765626,
          "end": 6771976,
          "strand": "-",
          "slug": "or2ag2"
        },
        {
          "symbol": "OR2AG1",
          "ensemblId": "ENSG00000279486",
          "biotype": "protein_coding",
          "start": 6783020,
          "end": 6791558,
          "strand": "+",
          "slug": "or2ag1"
        },
        {
          "symbol": "OR6A2",
          "ensemblId": "ENSG00000184933",
          "biotype": "protein_coding",
          "start": 6791736,
          "end": 6799689,
          "strand": "-",
          "slug": "or6a2"
        },
        {
          "symbol": "OR10A5",
          "ensemblId": "ENSG00000166363",
          "biotype": "protein_coding",
          "start": 6845683,
          "end": 6846636,
          "strand": "+",
          "slug": "or10a5"
        },
        {
          "symbol": "OR10A2",
          "ensemblId": "ENSG00000170790",
          "biotype": "protein_coding",
          "start": 6863057,
          "end": 6874717,
          "strand": "+",
          "slug": "or10a2"
        },
        {
          "symbol": "OR10A4",
          "ensemblId": "ENSG00000170782",
          "biotype": "protein_coding",
          "start": 6876625,
          "end": 6877619,
          "strand": "+",
          "slug": "or10a4"
        },
        {
          "symbol": "OR2D2",
          "ensemblId": "ENSG00000166368",
          "biotype": "protein_coding",
          "start": 6891574,
          "end": 6892500,
          "strand": "-",
          "slug": "or2d2"
        },
        {
          "symbol": "OR2D3",
          "ensemblId": "ENSG00000178358",
          "biotype": "protein_coding",
          "start": 6921002,
          "end": 6921994,
          "strand": "+",
          "slug": "or2d3"
        },
        {
          "symbol": "ZNF215",
          "ensemblId": "ENSG00000149054",
          "biotype": "protein_coding",
          "start": 6926343,
          "end": 7001004,
          "strand": "+",
          "slug": "znf215"
        },
        {
          "symbol": "ZNF214",
          "ensemblId": "ENSG00000149050",
          "biotype": "protein_coding",
          "start": 6996643,
          "end": 7020385,
          "strand": "-",
          "slug": "znf214"
        },
        {
          "symbol": "NLRP14",
          "ensemblId": "ENSG00000158077",
          "biotype": "protein_coding",
          "start": 7020462,
          "end": 7072055,
          "strand": "+",
          "slug": "nlrp14"
        },
        {
          "symbol": "RBMXL2",
          "ensemblId": "ENSG00000170748",
          "biotype": "protein_coding",
          "start": 7088998,
          "end": 7091148,
          "strand": "+",
          "slug": "rbmxl2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "neuronal-ceroid-lipofuscinosis",
        "name": "Νευρωνική Κεροειδής Λιποφουσκίνωση",
        "diseases": [
          {
            "mondoId": "MONDO:0016295",
            "name": "Νευρωνική Κεροειδής Λιποφουσκίνωση",
            "genes": 13,
            "inheritance": "autosomal-recessive",
            "description": "Μια ομάδα κληρονομικών προοδευτικών εκφυλιστικών νοσημάτων του εγκεφάλου, που κλινικά χαρακτηρίζονται από μείωση των νοητικών και άλλων ικανοτήτων, επιληψία και απώλεια όρασης λόγω εκφύλισης του αμφιβληστροειδούς, και ιστοπαθολογικά από ενδοκυττάρια συσσώρευση ενός αυτοφθορίζοντος υλικού, της κεροειδούς λιποφουσκίνης, στα νευρικά κύτταρα του εγκεφάλου και του αμφιβληστροειδούς.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "Myriad Women's Health",
                "Natera",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/el/conditions/neuronal-ceroid-lipofuscinosis"
      },
      {
        "slug": "autosomal-recessive-cerebellar-ataxias",
        "name": "Αυτοσωμικές υπολειπόμενες cerebellar αταξίες (συμπεριλαμβανομένων των CANVAS και AVED)",
        "diseases": [
          {
            "mondoId": "MONDO:0015244",
            "name": "Αυτοσωμική υπολειπόμενη cerebellar αταξία",
            "genes": 57,
            "inheritance": "autosomal-recessive",
            "description": "Μια ομάδα υπολειπόμενα κληρονομούμενων αταξιών που προκαλούνται από διαλληλικές μεταβολές σε γονίδια όπως τα RFC1, FXN, SACS, TTPA, SETX, APTX, PNKP, ANO10 και SYNE1.",
            "management": "Η αταξία με ανεπάρκεια βιταμίνης Ε (TTPA) αντιμετωπίζεται με συμπληρώματα βιταμίνης Ε· οι άλλες μορφές διαχειρίζονται με φυσιοθεραπεία και φροντίδα των συμπτωμάτων, και στους συγγενείς μπορεί να προσφερθεί έλεγχος φορέα.",
            "evidence": {
              "gencc": [
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/el/conditions/autosomal-recessive-cerebellar-ataxias"
      },
      {
        "slug": "lysosomal-storage-disease",
        "name": "Λυσοσωμική αποθησαυριστική νόσος",
        "diseases": [
          {
            "mondoId": "MONDO:0002561",
            "name": "Λυσοσωμική αποθησαυριστική νόσος (άλλοι και μη προσδιορισμένοι τύποι)",
            "genes": 59,
            "inheritance": null,
            "description": "Καλύπτει λυσοσωμικές αποθησαυριστικές νόσους χωρίς ειδική αναφορά, όπως η νόσος Farber και άλλες διαταραχές που σχετίζονται με το ASAH1, ελλείψεις προσαπσίνης (PSAP), πολλαπλή ελλειψη σουλφατάσης, μουκοπολυσακχαριδώσεις τύπων IX και X, και η νόσος Dorfman-Chanarin· ο τρόπος κληρονομικότητας διαφέρει ανάλογα με τον υποτύπο, συχνότερα αυτοσωμικός υπολειπόμενος.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "Myriad Women's Health",
                "Natera",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/el/conditions/lysosomal-storage-disease"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "gait-disturbance",
        "name": "Abnormal gait",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/gait-disturbance"
      },
      {
        "slug": "abnormal-nervous-system-electrophysiology",
        "name": "Abnormal nervous system electrophysiology",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/abnormal-nervous-system-electrophysiology"
      },
      {
        "slug": "ataxia",
        "name": "Ataxia",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/ataxia"
      },
      {
        "slug": "babinski-sign",
        "name": "Babinski sign",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/babinski-sign"
      },
      {
        "slug": "clumsiness",
        "name": "Clumsiness",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/clumsiness"
      },
      {
        "slug": "curvilinear-intracellular-accumulation-of-autofluorescent-lipopigment-storage-material",
        "name": "Curvilinear intracellular accumulation of autofluorescent lipopigment storage material",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/curvilinear-intracellular-accumulation-of-autofluorescent-lipopigment-storage-material"
      },
      {
        "slug": "cerebellar-atrophy",
        "name": "Degeneration of cerebellum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/cerebellar-atrophy"
      },
      {
        "slug": "cerebral-atrophy",
        "name": "Degeneration of cerebrum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/cerebral-atrophy"
      },
      {
        "slug": "delayed-speech-and-language-development",
        "name": "Delayed speech and language development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/delayed-speech-and-language-development"
      },
      {
        "slug": "dysarthria",
        "name": "Difficulty articulating speech",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dysarthria"
      },
      {
        "slug": "diplopia",
        "name": "Double vision",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/diplopia"
      },
      {
        "slug": "emg-neuropathic-changes",
        "name": "EMG: neuropathic changes",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/emg-neuropathic-changes"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "scanning-speech",
        "name": "Explosive speech",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/scanning-speech"
      },
      {
        "slug": "horizontal-nystagmus",
        "name": "Horizontal nystagmus",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/horizontal-nystagmus"
      },
      {
        "slug": "hypermetric-saccades",
        "name": "Hypermetric saccades",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypermetric-saccades"
      },
      {
        "slug": "impaired-vibratory-sensation",
        "name": "Impaired vibratory sensation",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/impaired-vibratory-sensation"
      },
      {
        "slug": "gait-ataxia",
        "name": "Inability to coordinate movements when walking",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gait-ataxia"
      },
      {
        "slug": "increased-extraneuronal-autofluorescent-lipopigment",
        "name": "Increased extraneuronal autofluorescent lipopigment",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/increased-extraneuronal-autofluorescent-lipopigment"
      },
      {
        "slug": "increased-neuronal-autofluorescent-lipopigment",
        "name": "Increased neuronal autofluorescent lipopigment",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/increased-neuronal-autofluorescent-lipopigment"
      },
      {
        "slug": "hyperreflexia",
        "name": "Increased reflexes",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperreflexia"
      },
      {
        "slug": "nystagmus",
        "name": "Involuntary, rapid, rhythmic eye movements",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/nystagmus"
      },
      {
        "slug": "myoclonus",
        "name": "Jerking",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/myoclonus"
      },
      {
        "slug": "dysmetria",
        "name": "Lack of coordination of movement",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dysmetria"
      },
      {
        "slug": "limb-ataxia",
        "name": "Limb ataxia",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/limb-ataxia"
      },
      {
        "slug": "developmental-regression",
        "name": "Loss of developmental milestones",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/developmental-regression"
      },
      {
        "slug": "oculomotor-apraxia",
        "name": "Oculomotor apraxia",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/oculomotor-apraxia"
      },
      {
        "slug": "dysphagia",
        "name": "Poor swallowing",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dysphagia"
      },
      {
        "slug": "postural-tremor",
        "name": "Postural tremor",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/postural-tremor"
      },
      {
        "slug": "progressive-cerebellar-ataxia",
        "name": "Progressive cerebellar ataxia",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/progressive-cerebellar-ataxia"
      },
      {
        "slug": "progressive-gait-ataxia",
        "name": "Progressive gait ataxia",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/progressive-gait-ataxia"
      },
      {
        "slug": "progressive-visual-loss",
        "name": "Progressive loss of vision",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/progressive-visual-loss"
      },
      {
        "slug": "reduced-tissue-tripeptidyl-peptidase-1-activity",
        "name": "Reduced tissue tripeptidyl peptidase 1 activity",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reduced-tissue-tripeptidyl-peptidase-1-activity"
      },
      {
        "slug": "retinal-degeneration",
        "name": "Retina degeneration",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/retinal-degeneration"
      },
      {
        "slug": "saccadic-smooth-pursuit-interruptions",
        "name": "Saccadic smooth pursuit interruptions",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/saccadic-smooth-pursuit-interruptions"
      },
      {
        "slug": "truncal-titubation",
        "name": "Truncal titubation",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/truncal-titubation"
      },
      {
        "slug": "dysmetric-saccades",
        "name": "Uncoordinated eye movement",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dysmetric-saccades"
      },
      {
        "slug": "undetectable-electroretinogram",
        "name": "Undetectable electroretinogram",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/undetectable-electroretinogram"
      },
      {
        "slug": "unsteady-gait",
        "name": "Unsteady walk",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/unsteady-gait"
      },
      {
        "slug": "urinary-urgency",
        "name": "Urinary urgency",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/urinary-urgency"
      },
      {
        "slug": "broad-based-gait",
        "name": "Wide based walk",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/broad-based-gait"
      }
    ],
    "related": [
      {
        "slug": "clcn6",
        "symbol": "CLCN6",
        "name": "Cl-/H+ antiporter 6",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/clcn6"
      },
      {
        "slug": "cln3",
        "symbol": "CLN3",
        "name": "CLN3 lysosomal/endosomal transmembrane protein, battenin",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/cln3"
      },
      {
        "slug": "cln5",
        "symbol": "CLN5",
        "name": "CLN5 lysosomal BMP synthase",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/cln5"
      },
      {
        "slug": "cln6",
        "symbol": "CLN6",
        "name": "CLN6 transmembrane ER protein",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/cln6"
      },
      {
        "slug": "cln8",
        "symbol": "CLN8",
        "name": "CLN8 transmembrane ER and ERGIC protein",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/cln8"
      },
      {
        "slug": "ctsd",
        "symbol": "CTSD",
        "name": "cathepsin D",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/ctsd"
      },
      {
        "slug": "ctsf",
        "symbol": "CTSF",
        "name": "cathepsin F",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/ctsf"
      },
      {
        "slug": "cyp27a1",
        "symbol": "CYP27A1",
        "name": "cytochrome P450 family 27 subfamily A member 1",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/cyp27a1"
      },
      {
        "slug": "dnajc5",
        "symbol": "DNAJC5",
        "name": "DnaJ heat shock protein family (Hsp40) member C5",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/dnajc5"
      },
      {
        "slug": "grn",
        "symbol": "GRN",
        "name": "granulin precursor",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/grn"
      },
      {
        "slug": "kctd7",
        "symbol": "KCTD7",
        "name": "potassium channel tetramerization domain containing 7",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/kctd7"
      },
      {
        "slug": "mfsd8",
        "symbol": "MFSD8",
        "name": "major facilitator superfamily domain containing 8",
        "shared": 2,
        "url": "https://dantelabs.com/el/genes/mfsd8"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}